Researchers have discovered that in Nav1.2 deficient neurons, the expressions of many potassium channels are surprisingly reduced. The Nav1.2 deficiency itself doesn't cause seizures; the issue arises when the potassium channels over-compensate for the sodium channels' deficiency by shutting down too many potassium channels, making the neuron hyperexcitable, which causes seizures.
A possible new pathway for treating epileptic seizures in patients with autism
- ScienceDaily
- 15. 9 2021 (00:47)