Biologists capture fleeting interactions between regulatory proteins and their genome-wide targets

New York University biologists captured highly transient interactions between transcription factors -- proteins that control gene expression -- and target genes in the genome and showed that these typically missed interactions have important practical implications. In a new study published in Nature Communications, the researchers developed a method to capture transient interactions of NLP7, a master transcription factor involved in nitrogen use in plants, revealing that the majority of a plant's response to nitrogen is controlled by these short-lived regulatory interactions.