Scientists have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking how enzymes are naturally regulated within cells.
Enzyme Inhibitor Takes An Unexpected Approach Toward Blocking Cancer-promoting Protein
- ScienceDaily
- 8. 9 2009 (06:00)