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169,451 articles from EurekAlert

'What wound did ever heal but by degrees?' delayed wound healing due to gene mutations

Scientists at Fujita Health University, Japan, have discovered how deficiencies of the IL-36Ra protein -- caused by mutations in the IL36RN gene -- delay wound healing via the flooding of the wound with several types of immune cells. However, by inhibiting the functioning of proteins and the signaling pathways involved in activating the immune system at a wound, this delay can be offset. These...

A heart-breast cancer-on-a-chip monitoring system

Dual-organ system enables the measurement of cardiac toxicity arising from breast cancer chemotherapy. A collaborative team, which includes a group from the Terasaki Institute for Biomedical Innovation, has developed an organs-on-a-chip system that more widely examines the responses of breast cancer and heart tissues to therapeutic breast cancer drugs.

A molecular break for root growth

The dynamic change in root growth of plants plays an important role in their adjustment to soil conditions. Depending on the location, nutrients or moisture can be found in higher or lower soil layers. This is why, depending on the situation, a short or a long root is advantageous. Caroline Gutjahr, Professor of Plant Genetics at the Technical University of Munich (TUM), and her team investigate...

A simple, cost-effective molecular assay may help manage growing spread of drug-resistant gonorrhea

A drug-resistant strain of the Neisseria (N.) gonorrhoeae has emerged around the world with the potential to make gonorrhea untreatable. The currently used screening methods for antimicrobial resistant (AMR) determinants are slow, expensive, and not widely available. In an article in The Journal of Molecular Diagnostics researchers report a rapid and cheap method that can provide real-time...

Aged cell variations may control health and onset of age-related diseases

Researchers from Kumamoto University, Japan have proposed that cellular senescence variations during the aging process could lead to control of health and onset of age-related diseases. Based on the characteristics of the secretion of inflammatory cytokines released by aged cells, they hypothesize that there are at least four distinct states of cellular senescence, and that these four states arise...

ALS and frontotemporal dementia: early diagnosis thanks to an experimental test

A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not yet appeared: a new methodology succeeds in detecting the protein TDP-43 - the same that accumulates in the brain of patients - even when it is present in minute quantities in the body. Since there are currently no treatments that can interfere with the course of the two diseases, early detection could...

Ancient lake contributed to past San Andreas fault ruptures

he San Andreas fault, which runs along the western coast of North America and crosses dense population centers like Los Angeles, California, is one of the most-studied faults in North America because of its significant hazard risk. Based on its roughly 150-year recurrence interval for magnitude 7.5 earthquakes and the fact that it's been over 300 years since that's happened, the southern San...

Bridges with limb-inspired architecture can withstand earthquakes, cut repair costs

Structural damage to any of the nation's ailing bridges can come with a hefty price of billions of dollars in repairs. New bridge designs promise more damage-resistant structures and, consequently, lower restoration costs. But if these designs haven't been implemented in the real world, predicting how they can be damaged and what repair strategies should be implemented remain unresolved.

Can scientists take the STING out of common respiratory viruses?

University of North Carolina School of Medicine scientists have made a curious discovery about a well-known human protein that helps the immune system fight viral infections. The lab of Stan Lemon MD, and colleagues found that one class of viruses actually requires this protein to infect cells and replicate.

City, University of London academics develop algorithm to analyse HeLa cancer cells

Dr Constantino Carlos Reyes-Aldasoro and Dr Cefa Karabag collaborate with the Francis Crick Institute on a novel approach published in the PLoS ONE journal, which significantly reduces the amount of time taken to analyse the cell line named after Henrietta Lacks, an African-American woman whose contribution to medical science was only formally acknowledged decades after her death.

Concrete structure's lifespan extended by a carbon textile

The Korea Institute of Civil Engineering and Building Technology (KICT) has announced the development of an effective structural strengthening method using a noncombustible carbon textile grid and cement mortar, which can double the load-bearing capacities of structurally deficient concrete structures and increase their usable lifespan by threefold.

Coronavirus volunteers: Greater satisfaction thanks to online platforms

Shortly after the lockdown began, a huge number of volunteers signed up to help people in coronavirus risk groups - primarily via online platforms. A study by the University of Basel has found that websites such as these can have a positive impact with regard to the mobilization, willingness and satisfaction of volunteers, including in the longer term.