Gd-doped nanoclusters help imaging of early orthotopic cancer

To realize precise diagnosis of early-stage cancer for effective treatment and better prognosis, high-resolution magnetic resonance imaging (MRI) is indispensable with the help of contrast agents. Iron-oxide-based T2 MR contrast agent (IOCA) is facing severe question of strong ferromagnetism and thereby weak T2 contrast ability. Although numerous efforts have been devoted to enhance the contrast ability of IOCAs, such as gadolinium ions (Gd3+) doping, the specific role that Gd3+ played in this process remained unclear.