(NEW YORK) — Larry Tesler, the Silicon Valley pioneer who created the now-ubiquitous computer concepts such as “cut,” “copy” and “paste,” has died. He was 74. He made using computers easier for generations as a proponent and pioneer of what he called “modeless editing.” That meant a user wouldn’t have to use a keyboard to switch between...

Larry Tesler, the Silicon Valley pioneer who created the now-ubiquitous computer concepts such as "cut," "copy" and "paste," has died. He was...

Spacecraft completes first critical stage of mission after successful deployment of boom armThe European Space Agency’s Solar Orbiter has completed the first critical stage of its mission. Launched on 10 February from Cape Canaveral, Florida, the spacecraft has sent back its first readings after the deployment of its 4.4 metre-long boom arm.Made of titanium and carbon fibre, the boom arm points...

Enough water will come from the ground as a byproduct of oil production from unconventional reservoirs during the coming decades to theoretically counter the need to use fresh water for hydraulic fracturing operations in many of the nation's large oil-producing areas. But while other industries, such as agriculture, might want to recycle some of that water for their own needs, water quality issues...

To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive. Research points to a weakness of previous testing and evaluation methods and provides a new hormone testing regime that offers better results.

In a comparison of 0.25mg/kg and 0.40mg/kg doses of the newer and more convenient clot-busting medication tenecteplase, there was no advantage in increasing the dose above 0.25mg/kg in stroke patients who planned to have mechanical clot retrieval. In addition, administering tenecteplase may decrease the need for mechanical clot removal.

After 50 years of research and the testing of over 1,000 drugs, there is new hope for preserving brain cells for a time after stroke. Treating acute ischemic stroke patients with an experimental neuroprotective drug, combined with a surgical procedure to remove the clot improves outcomes as shown by clinical trial results.

A team took a novel, interdisciplinary approach to analyzing the behavior of breast tumor cells by employing a statistical modeling technique more commonly used in physics and economics. The team was able to demonstrate how the diversity, or heterogeneity, of cancer cells can be influenced by their chemical environment -- namely, by interactions with a specific protein, which leads to tumor...

Enough water will come from the ground as a byproduct of oil production from unconventional reservoirs during the coming decades to theoretically counter the need to use fresh water for hydraulic fracturing operations in many of the nation's large oil-producing areas. While other industries might want to recycle some of that water for their own needs, water quality issues and the potential costs...

Conservative leadership hopeful Peter MacKay is facing blowback after posting and then deleting a tweet that expressed support for counter-protesters who dismantled a barricade erected by supporters of the Wet’suwet’en hereditary chiefs near Edmonton on...

The CEO of Telus Corp. says it could cut about $1 billion of spending and 5,000 jobs over the next five years if the CRTC mandates Canada's wireless companies open their facilities to virtual network...

In this week's issue of our environment newsletter, we try a week of zero-waste grocery shopping and look at how climate change is likely to affect the farmable parts of Canada.

The massive Colorado River, which provides water for seven US states, has seen its flow reduced by 20 percent over the course of a century—and more than half of that loss is due to climate change, according to new research published Thursday.

It's not easy to do pregnancy tests on whales. You can't just ask a wild ocean animal that's the size of a school bus to pee on a little stick. For decades, the only way scientists could count pregnant females was by sight and best guesses based on visual characteristics. For the last several years, researchers have relied on hormone tests of blubber collected via darts, but the results were often...

Surprising new data from NASA's Hubble Space Telescope suggests the smooth, settled "brim" of the Sombrero galaxy's disk may be concealing a turbulent past. Hubble's sharpness and sensitivity resolves tens of thousands of individual stars in the Sombrero's vast, extended halo, the region beyond a galaxy's central portion, typically made of older stars. These latest observations of the Sombrero are...

A growing body of research shows that birds' spring migration has been getting earlier and earlier in recent decades. New research on Black-throated Blue Warblers, a common songbird that migrates from Canada and the eastern US to Central America and back every year, uses fifty years of bird-banding data to add another piece to the puzzle, showing that little-studied fall migration patterns have...

The monkeyflower, or Mimulus, though possessing a relatively simple genome is able to produce a stunning array of pigmentation patterns. A team of researchers is one step closer to understanding exactly how this genus of wildflowers is able to achieve such remarkable diversity.

Using a machine-learning algorithm, researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models.

The ability to recognize objects across different senses is present in the tiny brains of an insect, researchers have discovered.

Scientists show for the first time that a newer type of CRISPR, called base-editing, can safely cure cystic fibrosis in stem cells derived from patients.

Scientists find that normal intestinal cells 'de-differentiate' en masse into stem cells that generate the cells needed for a healthy intestinal lining. New study establishes de-differentiation as the predominant mode of stem cell recover in the intestine.

Researchers describe the science behind creating lighting to make us all happy and productive indoors. A company is using the technology to create commercial lightbulbs available later this year.

Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. The treatment does not harm these humanized cells.

Scientists have made an important discovery with implications for those living with a common, debilitating eye disease (age-related macular degeneration, AMD) that can cause blindness. They have discovered that the molecule TLR2, which recognises chemical patterns associated with infection in the body, also seems to play an important role in the development of retinal degeneration. When TLR2 is...

New work shows how using next-generation DNA sequencing on ancient packrat middens -- nests made out of plant material, fragments of insects, bones, fecal matter, and urine -- could provide ecological snapshots of Earth's past. The study may pave the way for scientists to better understand how plant communities -- and possibly animals, bacteria, and fungi as well -- will respond to human-caused...

To combat supply chain counterfeiting, which can cost companies billions of dollars annually, researchers have invented a cryptographic ID tag that's small enough to fit on virtually any product and verify its authenticity.

Researchers have invented a new method -- using ultraflat gold films -- to disassemble vdW single crystals layer by layer into monolayers with near-unity yield and with dimensions limited only by bulk crystal sizes. The monolayers have the same high quality as those created by conventional 'Scotch tape' exfoliation, but are roughly a million times larger. They can be assembled into macroscopic...

Investigators successfully measure brain temperature in newborn babies undergoing therapeutic cooling, showing that the treatment effectively targets the core of the brain.

A first cell atlas of the human thymus gland could lead to new immune therapies to treat cancer and autoimmune diseases. Researchers mapped thymus tissue through the human lifespan to understand how it develops and makes vital immune cells called T cells. In the future, this information could help researchers to generate an artificial thymus and engineer improved therapeutic T cells.

Underwater archeologists from Parks Canada found highly personal items as they recovered more than 350 artifacts during their most recent - and they say most successful - season yet at the HMS Erebus wreck site off the coast of...

A new study documented the earliest known interbreeding event between ancient human populations -- a group known as the 'super-archaics' in Eurasia interbred with a Neanderthal-Denisovan ancestor about 700,000 years ago. The event was between two populations more distantly related than any other recorded. The authors proposed a revised timeline for human migration out of Africa and into Eurasia....

Turquoise killifish is able to suspend its development for longer than its average lifespanThe curious ability of the African turquoise killifish to press pause on its development could have intriguing implications for human ageing, say researchers.Certain creatures, including the killifish, can put themselves into suspended animation as an embryo – a trait known as diapause. The phenomenon is...

For three years, anthropologist Alan Rogers has attempted to solve an evolutionary puzzle. His research untangles millions of years of human evolution by analyzing DNA strands from ancient human species known as hominins. Like many evolutionary geneticists, Rogers compares hominin genomes looking for genetic patterns such as mutations and shared genes. He develops statistical methods that infer...

Permafrost in the soil and methane hydrates deep in the ocean are large reservoirs of ancient carbon. As soil and ocean temperatures rise, the reservoirs have the potential to break down, releasing enormous quantities of the potent greenhouse gas methane. But would this methane actually make it to the atmosphere?

Two-dimensional materials from layered van der Waals (vdW) crystals hold great promise for electronic, optoelectronic, and quantum devices, but making/manufacturing them has been limited by the lack of high-throughput techniques for exfoliating single-crystal monolayers with sufficient size and high quality. Columbia University researchers report today in Science that they have invented a new...

How are we able to find things in the dark? And how can we imagine how something feels just by looking at it?

These latest Hubble observations of the Sombrero galaxy indicate only a tiny fraction of older, metal-poor stars in the halo, plus an unexpected abundance of metal-rich stars. Past major galaxy mergers are a possible explanation, though the stately Sombrero shows none of the messy evidence of a recent merger of massive galaxies.

The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we...

A myriad of cellular events are regulated by allostery; therefore, evolution of this process is of fundamental interest. Here, we use ancestral sequence reconstruction to resurrect ancestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2 (targeting protein for Xklp2), to experimentally characterize the evolutionary path of allosteric activation. Autophosphorylation...

Biased agonists of G protein–coupled receptors (GPCRs) preferentially activate a subset of downstream signaling pathways. In this work, we present crystal structures of angiotensin II type 1 receptor (AT1R) (2.7 to 2.9 angstroms) bound to three ligands with divergent bias profiles: the balanced endogenous agonist angiotensin II (AngII) and two strongly β-arrestin–biased analogs....

Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of pharmaceuticals, agrochemicals, aroma chemicals, and materials. In many cases, the arrangement of substituents in the macrocycle imparts an element of planar chirality. The difficulty in predicting when planar chirality will arise, as well as the...