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64 articles from ScienceDaily

Scientists decipher role of a stress response gene

A team of scientists is shedding new light on the gene regulatory pathways activated by cortisol, a hormone secreted in response to stress. Their research helps explain why exposure to chronic stress early in life shortens lifespan and contribute to age-related chronic diseases later in life -- long after the source of stress has been removed.

Designed antiviral proteins inhibit SARS-CoV-2 in the lab

Computer-designed miniproteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19. The lead antiviral candidate rivals the best-known SARS-CoV-2 monoclonal antibodies in its protective actions. The synthetic antiviral candidates were designed to prevent infection by interfering with the mechanism that coronaviruses use to break into and enter...

Caffeine shot delivers wake-up call on antifungal drug resistance

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs. It was previously thought that only mutations in a fungi's DNA would result in antifungal drug resistance. Current diagnostic techniques rely on sequencing all of a fungi's DNA to find such mutations. Scientists have now discovered that fungi can...

Biological roots for teen risk-taking: Uneven brain growth

Why do some adolescents take more risks than others? Research suggests that two centers in the brain, one which makes adolescents want to take risks and the other which prevents them from acting on these impulses, physically mature at different rates and that adolescents with large differences in the rate of development between these two brain regions are more likely to be risk-takers.

Artificial intelligence aids gene activation discovery

Scientists have long known that human genes are activated through instructions delivered by the precise order of our DNA. With the aid of artificial intelligence, researchers have solved a long-standing DNA activation code mystery. Their discovery, which they termed the downstream core promoter region (DPR), could eventually be used to control gene activation in biotechnology and biomedical...

Atomistic modelling probes the behavior of matter at the center of Jupiter

Scientists have developed a physics-based machine learning approach to examine the behavior of hydrogen at extremely high pressures. The model reveals evidence of continuous metalization, and so has significant implications for planetary science. More fundamentally, it shows the way ahead for a simulation-driven change in how we understand the behavior of matter in fields as diverse as drug...

Generic cholesterol drugs save Medicare billions of dollars

The switch from brand name to generic cholesterol medications that occurred between 2014 and 2018 has saved Medicare billions of dollars, even as the number of people on cholesterol-lowering drugs has increased, scientists have calculated. Their data suggest that policymakers and clinicians could help cut Medicare costs even further by switching more patients to generic drugs.

New method prevents quantum computers from crashing

Quantum information is fragile, which is why quantum computers must be able to correct errors. But what if whole qubits are lost? Researchers are now presenting a method that allows quantum computers to keep going even if they lose some qubits along the way.

Allergic immune responses help fight bacterial infections

Researchers have found that a module of the immune system, best known for causing allergic reactions, plays a key role in acquiring host defense against infections triggered by the bacterium Staphylococcus aureus. This allergy module, constituted by mast cells and Immunoglobulin E, can grant protection and increased resistance against secondary bacterial infections in the body. These findings...

Women's heart health linked to age at first menstrual period

Early menarche has been associated with many cardiovascular disease (CVD) risk factors, but little is known about its association with overall heart health. One new study suggests that age at menarche plays an important role in maintaining and improving cardiovascular health, although there are a number of age differences.

Cell-autonomous immunity shaped human evolution

Every human cell harbors its own defenses against microbial invaders, relying on strategies that date back to some of the earliest events in the history of life, researchers report. Because this 'cell-autonomous immunity' is so ancient and persistent, understanding it is essential to understanding human evolution and human medicine, the researchers said.