220 articles from TUESDAY 5.1.2021

How to cope with the winter lockdown in the UK

Lockdown in bad weather with little natural light seems daunting but there are routines and techniques that can help usWith new national lockdowns coming into force across the UK, we take a look at how to cope – from staying connected to getting out in the open. Continue reading...

Machine learning improves particle accelerator diagnostics

Operators of the primary particle accelerator at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility are getting a new tool to help them quickly address issues that can prevent it from running smoothly. A new machine learning system has passed its first two-week test, correctly identifying glitchy accelerator components and the type of glitches they're experiencing in...

Breaking through the resolution barrier with quantum-limited precision

Researchers at Paderborn University have developed a new method of distance measurement for systems such as GPS, which achieves more precise results than ever before. Using quantum physics, the team led by Leibniz Prize winner Professor Christine Silberhorn has successfully overcome the so-called resolution limit, which causes the 'noise' we may see in photos, for example. Their findings have just...

Diet and lifestyle guidelines can greatly reduce gastroesophageal reflux disease symptoms

Gastroesophageal reflux disease is a common condition affecting 30 percent of the US population and often controlled with medication. While doctors commonly recommend specific dietary and lifestyle changes to control symptoms, there is little evidence about their effectiveness. Results of a large-scale study suggest such changes, including regular exercise, can reduce symptoms substantially.

Machine learning improves particle accelerator diagnostics

Operators of Jefferson Lab's primary particle accelerator are getting a new tool to help them quickly address issues that can prevent it from running smoothly. The machine learning system has passed its first two-week test, correctly identifying glitchy accelerator components and the type of glitches they're experiencing in near-real-time. An analysis of the results of the first field test of the...

Magnets dim natural glow of human cells, may shed light on how animals migrate

New research shows how X-Men villain Magneto's super powers could really work. Researchers have made the first observations of biological magnetoreception - live, unaltered cells responding to a magnetic field in real time. This discovery is a crucial step in understanding how animals from birds to butterflies navigate using Earth's magnetic field and addressing the question of whether weak...

Anticoagulants reduce the number of brain metastases in mice

Brain metastases can only develop if cancer cells exit the capillaries and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as scientists have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the brain capillaries and then penetrate through the vessel wall. Drugs that inhibit thrombin...

Making therapeutic sense of antisense oligonucleotides

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide (HDO) model, have demonstrated augmentation of ASO-based drugs by replacing the RNA strand with DNA.

DeepTFactor predicts transcription factors

A joint research team from KAIST and UCSD has developed a deep neural network named DeepTFactor that predicts transcription factors from protein sequences. DeepTFactor will serve as a useful tool for understanding the regulatory systems of organisms, accelerating the use of deep learning for solving biological problems.

Integrator: A guardian of the human transcriptome

In a joint collaboration, Danish and German researchers have characterized a cellular activity that protects our cells from potentially toxic by-products of gene expression. This activity is central for the ability of multicellular organisms to uphold a robust evolutionary 'reservoir' of gene products.

Change in the weather: German storm names to be more diverse

Symbolic #WeatherCorrection is part of campaign for inclusivity in societyMove over, Siegfried. Ahmet is on the way.A journalists’ group has named a low pressure system bringing low temperatures, dark clouds and snow to Germany after the boy’s name of Turkish origin in an effort to increase the visibility of the country’s increasingly diverse population. Continue...

Neither liquid nor solid

Discovery of liquid glass sheds light on the old scientific problem of the glass transition: An interdisciplinary team of researchers has uncovered a new state of matter, liquid glass, with previously unknown structural elements - new insights into the nature of glass and its transitions.

Potential treatment for an aggressive form of lung cancer

Researchers have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer (NSCLC). These findings could pave the way for new treatments for patients with mutations in two key genes - KRAS and LKB1. Patients whose tumors contain both of these mutations, known as KL tumors, have poor outcomes and usually do not respond to immunotherapy.