319 articles from MONDAY 10.5.2021

SARS-CoV-2 research: Second possible effective mechanism of remdesivir discovered

After infection, SARS-CoV-2 causes the host cell to produce new virus particles and suppresses host cell defence mechanisms. Virus protein nsP3 plays a central role in the latter process. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the remdesivir binds to nsP3. This previously...

Scientists find mechanism that eliminates senescent cells

Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct -- or senescent -- cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.

Serotonin transporters increase when depression fades, study shows

Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy....

Small study shows heart damage after COVID-19 uncommon in college athletes

In a small study, 82% of the college athletes with COVID-19 had symptoms, of which the majority were mild and did not require treatment.Further screening via cardiac MRI of the 4% of athletes identified with heart abnormalities found no heart damage or inflammation.All athletes resumed regular training and competition without difficulty after recovering from COVID-19.

Smashing the Covid curve

Researchers at the IST Austria led by Björn Hof reports that a small difference in epidemic mitigation levels can cause a discontinuous jump in infection numbers. The researchers show that limits in testing and contact tracing are responsible for this sudden change in the epidemic outcome. Testing followed up by contact tracing is extremely efficient in slowing down epidemics, however, once...

Solving the cocktail party problem

Conducting a discussion in a crowded room can be challenging when other conversations and background noise interfere with our ability to focus attention on our conversation partner. Can we absorb information from a few speakers in parallel, or are we limited to understanding speech from only one speaker at a time? Researchers have now moved closer to understanding how the brain deals with the...

Study led by Penn Medicine reveals new mechanism of lung tissue regeneration

New research performed in mice models at Penn Medicine shows, mechanistically, how the infant lung regenerates cells after injury differently than the adult lung, with alveolar type 1 (AT1) cells reprograming into alveolar type 2 (AT2) cells (two very different lung alveolar epithelial cells), promoting cell regeneration, rather than AT2 cells differentiating into AT1 cells, which is the most...

TB immune response discovery could significantly reduce disease harm

A pioneering study by UCL scientists has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to infection, excessive and damaging lung inflammation caused by TB may be significantly reduced to help speed up patient recovery.

The 'key' to new COVID-19 vaccine development

An Iowa State University biomedical scientist is researching a new COVID-19 vaccine that would target only a small portion of the virus's spike protein. The vaccine has shown promise in laboratory experiments, and more vaccines could be necessary in the years ahead as additional SARS-CoV-2 variants emerge.

The Lancet Infectious Diseases: Non-hospitalised COVID-19 patients have low-risk of serious long-term effects, but report more visits to general practitioner following infection

A new study published in The Lancet Infectious Diseases journal has found that the risk of delayed acute complications after non-hospitalised SARS-CoV-2 infection is low, but persistent symptoms in this group could lead to increased visits to general practitioners or outpatient clinics in the six months following infection. The study assessed only those complications that led to contact with...

This system helps robots better navigate emergency rooms

Computer scientists at the University of California San Diego have developed a more accurate navigation system that will allow robots to better negotiate busy clinical environments in general and emergency departments more specifically. The researchers have also developed a dataset of open source videos to help train robotic navigation systems in the future. The team detail their findings in a...

THz emission spectroscopy reveals optical response of GaInN/GaN multiple quantum wells

An international team of researchers led by Osaka University came closer to unraveling the complicated optical response of wide-bandgap semiconductor multiple quantum wells and how atomic-scale lattice vibration can generate free space terahertz emission. Their work provides a significant push towards the application of laser terahertz emission microscopes to nano-seismology of wide-bandgap...

Timing is everything in new implant tech

Rice University engineers develop a new version of their wireless implant that allows for multiple stimulators to be programmed and magnetically powered from a single transmitter outside the body. The implants could be used to treat spinal cord injuries or as pacemakers.