SARS-CoV-2 research: Second possible effective mechanism of remdesivir discovered
319 articles from MONDAY 10.5.2021
Scientists develop better way to block viruses that cause childhood respiratory infections
After infection, SARS-CoV-2 causes the host cell to produce new virus particles and suppresses host cell defence mechanisms. Virus protein nsP3 plays a central role in the latter process. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the remdesivir binds to nsP3. This previously...
Scientists find mechanism that eliminates senescent cells
By engineering a short chunk of protein, or peptide, that can prevent the attachment of human parainfluenza viruses to cells, researchers have improved a method in rodent models intended to help keep children healthy.
Serotonin transporters increase when depression fades, study shows
Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct -- or senescent -- cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.
Sharks in protected area attract illegal fishers
Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy....
Should we panic over declining sperm counts? Harvard researchers say not so fast
Thousands of sharks have been illegally caught in a Marine Protected Area (MPA) in the Indian Ocean, new research shows.
Single-cell map of early stage lung cancer and normal lung sheds light on tumor development, new therapeutic targets
Recent studies have claimed that sperm counts among men globally, and especially from "Western" countries, are in decline, leading to apocalyptic claims about the possible extinction of the human species. The Harvard paper reanalyzes claims of precipitous human sperm declines, re-evaluating evidence.
Small study shows heart damage after COVID-19 uncommon in college athletes
MD Anderson researchers have developed a first-of-its-kind atlas of early-stage lung cancer and surrounding normal lung tissue. The single-cell map provides a valuable resource to learn about tumor development and find new therapeutic targets.
Smashing the Covid curve
In a small study, 82% of the college athletes with COVID-19 had symptoms, of which the majority were mild and did not require treatment.Further screening via cardiac MRI of the 4% of athletes identified with heart abnormalities found no heart damage or inflammation.All athletes resumed regular training and competition without difficulty after recovering from COVID-19.
Solving the cocktail party problem
Researchers at the IST Austria led by BjÃ¶rn Hof reports that a small difference in epidemic mitigation levels can cause a discontinuous jump in infection numbers. The researchers show that limits in testing and contact tracing are responsible for this sudden change in the epidemic outcome. Testing followed up by contact tracing is extremely efficient in slowing down epidemics, however, once...
Stanford researchers map how people in cities get a health boost from nature
Conducting a discussion in a crowded room can be challenging when other conversations and background noise interfere with our ability to focus attention on our conversation partner. Can we absorb information from a few speakers in parallel, or are we limited to understanding speech from only one speaker at a time? Researchers have now moved closer to understanding how the brain deals with the...
Study finds pretty plants hog research and conservation limelight
Trees lining a street may encourage people to take a longer stroll or choose to bike to work. New research shows how access to natural areas in cities can improve human health by supporting physical activity. The researchers plan to equip city planners with tools to create healthier, more sustainable cities around the world.
Study indicates São Tomé island has two species of caecilians found nowhere else on Earth
New Curtin University research has found a bias among scientists toward colourful and visually striking plants, means they are more likely to be chosen for scientific study and benefit from subsequent conservation efforts, regardless of their ecological importance.
Study led by Penn Medicine reveals new mechanism of lung tissue regeneration
A new study indicates SÃ£o TomÃ© island has two species of caecilians found nowhere else on Earth. The research adds evidence to a century-long scientific debate and reveals how volcanic activity may have driven the divergence of the limbless amphibians.
Study reveals mixed reactions about COVID-19 health disparities
New research performed in mice models at Penn Medicine shows, mechanistically, how the infant lung regenerates cells after injury differently than the adult lung, with alveolar type 1 (AT1) cells reprograming into alveolar type 2 (AT2) cells (two very different lung alveolar epithelial cells), promoting cell regeneration, rather than AT2 cells differentiating into AT1 cells, which is the most...
Synergistic effects of acoustics-based therapy and immunotherapy in cancer treatment
MIT political scientist Evan Lieberman is co-author of a new paper showing mixed reactions when people are informed of the racial disparities in Covid-19 outcomes in the U.S.
TB immune response discovery could significantly reduce disease harm
Announcing a new article publication for BIO Integration journal. In this review the authors Yuheng Bao, Jifan Chen, Pintong Huang and Weijun Tong from Zhejiang University, Hangzhou, China discuss the synergistic effects of acoustics-based therapy and immunotherapy in cancer treatment.
The 'key' to new COVID-19 vaccine development
A pioneering study by UCL scientists has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to infection, excessive and damaging lung inflammation caused by TB may be significantly reduced to help speed up patient recovery.
The formation of the Amazon Basin influenced the distribution of manatees
An Iowa State University biomedical scientist is researching a new COVID-19 vaccine that would target only a small portion of the virus's spike protein. The vaccine has shown promise in laboratory experiments, and more vaccines could be necessary in the years ahead as additional SARS-CoV-2 variants emerge.
The Lancet Infectious Diseases: Non-hospitalised COVID-19 patients have low-risk of serious long-term effects, but report more visits to general practitioner following infection
Whole mitochondrial DNA sequencing of the three extant species of the aquatic mammal shows that they first split from their common ancestor after geological events isolated the South American region from the sea. The African species may have originated in migration borne by marine currents.
The next generation of hunters could look different
A new study published in The Lancet Infectious Diseases journal has found that the risk of delayed acute complications after non-hospitalised SARS-CoV-2 infection is low, but persistent symptoms in this group could lead to increased visits to general practitioners or outpatient clinics in the six months following infection. The study assessed only those complications that led to contact with...
This system helps robots better navigate emergency rooms
A new survey led by researchers from North Carolina State University found that the future of hunting in the United States might look different than it has in the past.
THz emission spectroscopy reveals optical response of GaInN/GaN multiple quantum wells
Computer scientists at the University of California San Diego have developed a more accurate navigation system that will allow robots to better negotiate busy clinical environments in general and emergency departments more specifically. The researchers have also developed a dataset of open source videos to help train robotic navigation systems in the future. The team detail their findings in a...
Time running out to save coral reefs
An international team of researchers led by Osaka University came closer to unraveling the complicated optical response of wide-bandgap semiconductor multiple quantum wells and how atomic-scale lattice vibration can generate free space terahertz emission. Their work provides a significant push towards the application of laser terahertz emission microscopes to nano-seismology of wide-bandgap...
Timing is everything in new implant tech
New data on the growth rates of coral reefs shows there is still a window of opportunity to save them from eroding by mid-century--but time is running out.
Rice University engineers develop a new version of their wireless implant that allows for multiple stimulators to be programmed and magnetically powered from a single transmitter outside the body. The implants could be used to treat spinal cord injuries or as pacemakers.