319 articles from MONDAY 10.5.2021

CDK inhibitors may improve immune therapy effectiveness for recurrent breast cancer

A class of drugs that inhibits breast cancer progression when used with hormonal therapy might also boost the effectiveness of immune therapy in cases of recurrent, metastatic breast cancer, according to a new study led by researchers atThe Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Conservationists concerned about illegal hunting and exploitation of porcupines in Indonesia

Porcupines are being illegally hunted and exploited throughout their range in Indonesia for local subsistence and commercial trade. They are reportedly in decline, yet there seems to be little control or monitoring on uptake and trade. A new study examining seizure data of porcupines in Indonesia found a total of 39 incidents from January 2013 to June 2020 involving an estimated 452 porcupines....

Controlling cholesterol in microglia alleviates chronic pain, opioid-free

Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.

Differences between leopards are greater than between brown bears and polar bears

New research demonstrates that African and Asian leopards are more genetically differentiated from one another than polar bears and brown bears. Indeed, leopards are so different that they ought to be treated as two separate species, according to a team of researchers, among them, scientists from the University of Copenhagen. This new knowledge has important implications for better conserving this...

Do purines influence cancer development?

Numerous disease development processes are linked to epigenetic modulation. One protein involved in the process of modulation and identified as an important cancer marker is BRD4. A recent study by researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, now shows that the supply of purines as well as the purine synthesis of a cell can influence BRD4...

Even small bills for health insurance may cause healthy low-income people to drop coverage

Twenty dollars a month might not seem like a lot to pay for health insurance. But for people getting by on $15,000 a year, it's enough to make some drop their coverage - especially if they're healthy, a new study of Medicaid expansion participants in Michigan finds. That could keep them from getting preventive or timely care, and could leave their insurance company with a sicker pool of patients...

Firefighting chemical found in sea lion and fur seal pups

A chemical that the New South Wales government has recently partially banned in firefighting has been found in the pups of endangered Australian sea lions and in Australian fur seals. The finding represents another possible blow to Australian sea lions' survival. Hookworm and tuberculosis already threaten their small and diminishing population, which has fallen by more than 60 percent over four...

Flower size correlates with pollinator size, evolved independently among mountains

The morphological compatibility between flowers and insects was given in the famous textbook example of Darwin's orchids and hawkmoths. As in this example, many studies have shown that geographical variations in flower size match the size of insects in each region. In other words, studies have shown "flower-sized regional adaptation" in which large flowers evolve in areas pollinated by large...

Flying at up to Mach 16 could become reality with UCF's developing propulsion system

University of Central Florida researchers are building on their technology that could pave the way for hypersonic flight, such as travel from New York to Los Angeles in under 30 minutes. In their latest research published in the journal Proceedings of the National Academy of Sciences, the researchers discovered a way to stabilize the detonation needed for hypersonic propulsion by creating a...