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65 articles from ScienceDaily

Innovative surgical simulator is a significant advance in training trauma teams

Simulators have long been used for training surgeons and surgical teams, but traditional simulator platforms typically have a built-in limitation: they often simulate one or a limited number of conditions that require performance of isolated tasks, such as placing an intravenous catheter, instead of simulating and providing opportunities for feedback on the performance of multiple interventions...

Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington's disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientists have found that the targeting the protein called FK506-binding protein 51 or FKBP51 promotes the clearing of those toxic proteins via autophagy,...

New method to improve durability of nano-electronic components, further semiconductor manufacturing

Researchers have developed a novel approach to mitigating electromigration in nanoscale electronic interconnects that are ubiquitous in state-of-the-art integrated circuits. This was achieved by coating copper metal interconnects with hexagonal boron nitride (hBN), an atomically-thin insulating two-dimensional (2D) material that shares a similar structure as the 'wonder material' graphene.

Light shed on mysterious genotype-phenotype associations

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer's disease

Evidence of sleep-dependent low-frequency (less than 0.1 Hz) global brain activity in the clearance of Alzheimer's disease-related toxin buildup is presented in new research. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating...

'Self-aware' materials build the foundation for living structures

New research describes a new metamaterial system that acts as its own sensor, recording and relaying important information about the pressure and stresses on its structure. The so-called 'self-aware metamaterial' generates its own power and can be used for a wide array of sensing and monitoring applications.

Researchers discover gene linked to bone cancer in children, ID potential novel therapy

Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children. They have also identified a compound that shows potential to block OTUD7A protein activity. Critical relationships between proteins contribute to the development of cancers such as Ewing sarcoma. So, it was a seminal discovery when the researchers found that...

Parasites may accumulate in spleens of asymptomatic individuals infected with malaria

Malaria, a disease caused mainly by the parasites Plasmodium falciparum and Plasmodium vivax, is associated with over 400,000 deaths each year. Previously, the spleen was assumed to mostly play a role in parasite destruction, as it eliminates malaria parasites after antimalarial treatment. A new study suggests that in chronic P. vivax infections, malaria parasites survive and replicate via a...

Improved detection of atrial fibrillation could prevent disabling strokes

A clinical trial examining the efficacy of two devices to monitor and detect atrial fibrillation (AF), or an irregular heartbeat, in ischemic stroke patients -- one an implantable device that monitors over 12 months, the other an external device that monitors over a 30-day period -- found the implantable device is more than three times more effective in detecting AF.

How AI could alert firefighters of imminent danger

Researchers have developed an artificial-intelligence-powered tool to predict and warn of a deadly phenomenon in burning buildings known as flashover, when flammable materials in a room ignite almost simultaneously, producing a potentially ferocious blaze. The tool's predictions are based on temperature data from a building's heat detectors, and, remarkably, it is designed to operate even after...

Precise data for improved coastline protection

Researchers have conducted the first precise and comprehensive measurements of sea level rises in the Baltic Sea and the North Sea. A new method now makes it possible to determine sea level changes with millimeter accuracy even in coastal areas and in case of sea ice coverage. This is of vital importance for planning protective measures.