112 articles from MONDAY 9.5.2022

Methylation of tRNA-derived fragments regulates gene-silencing activity in bladder cancer

Researchers describe a novel form of gene regulation that is altered in bladder cancer, leading to the boosting of a gene pathway that helps the cancer cells survive during rapid growth. The work focuses on a 22-base fragment of transfer RNA, tRF-3b, which is modified by the enzyme complex TRMT6/61A. In bladder cancer, the levels of TRMT6/61A -- a methyltransferase -- are elevated. The methylation...

Citizen science study detects vast amount of microplastics in Catalan bathing areas

The presence of microplastics in the oceans is widely documented/reported by oceanographic research, but data on the pollution in the nearshore regions are scarce due to access difficulties faced by scientific boats. Researchers from the Consolidated Research Group on Marine Geosciences of the Faculty of Earth Sciences of the UB, in collaboration with the Spanish delegation of the NGO Surfrider...

How do water mold spores swim?

Oomycetes, also known as water moulds, are pathogenic microorganisms that resemble fungi and are responsible for a group of diseases affecting several plant species. To reach and infect plants, the spores swim to their target. Physicists and biologists have now precisely measured the movement of each flagellum while a zoospore follows a linear trajectory and when it is turning.

Drugs showing promise in cancer trials reduce scarring for scleroderma

Epigenetic drugs that have shown promise in cancer trials significantly reduce scarring in the cells of patients with scleroderma, a new study shows. Results reveal that drugs that inhibit BRD4, known to play a role in cancer, also affect fibrosis in scleroderma. Researchers tested BRD4 inhibitors on the skin fibroblasts of scleroderma patients and in mouse models of skin fibrosis, finding that...