Bioscientists have uncovered a tiny detail that could help us understand how DNA replicates with such astounding accuracy.

Researchers describe a novel form of gene regulation that is altered in bladder cancer, leading to the boosting of a gene pathway that helps the cancer cells survive during rapid growth. The work focuses on a 22-base fragment of transfer RNA, tRF-3b, which is modified by the enzyme complex TRMT6/61A. In bladder cancer, the levels of TRMT6/61A -- a methyltransferase -- are elevated. The methylation...

Ice shelves are floating extensions of glaciers. If Greenland's second largest ice shelf breaks up, it may not recover unless Earth's future climate cools considerably.

Global warming can result in the spread of peatland vegetation in the Arctic. An international research group has discovered signs of 'proto-peat', which may be the beginning of new peatlands.

Oomycetes, also known as water moulds, are pathogenic microorganisms that resemble fungi and are responsible for a group of diseases affecting several plant species. To reach and infect plants, the spores swim to their target. Physicists and biologists have now precisely measured the movement of each flagellum while a zoospore follows a linear trajectory and when it is turning.

New research shows that hypoxia can activate the same group of immune cells that cause inflammation during asthma attacks.

Epigenetic drugs that have shown promise in cancer trials significantly reduce scarring in the cells of patients with scleroderma, a new study shows. Results reveal that drugs that inhibit BRD4, known to play a role in cancer, also affect fibrosis in scleroderma. Researchers tested BRD4 inhibitors on the skin fibroblasts of scleroderma patients and in mouse models of skin fibrosis, finding that...

Researchers have been investigating an alternative treatment approach called adaptive therapy that focuses on maintaining disease control instead of complete tumor cell elimination. Researchers used mathematical modeling to reveal that the spatial organization of a tumor is an important factor that governs how cells compete with one another and the effectiveness of adaptive therapy.

Scientists investigating the underside of the world's largest ice sheet in East Antarctica have discovered a city-size lake whose sediments might answer questions about what Antarctica was like before it froze, how climate change has affected it over its history, and how the ice sheet might behave as the world warms.

The Westdahl Peak volcano in Alaska last erupted in 1992, and continued expansion hints at another eruption soon. Experts previously forecasted the next blast to occur by 2010, but the volcano -- located under about 1 kilometer of glacial ice -- has yet to erupt again. Using the Westdahl Peak volcano as inspiration, a new volcanic modeling study examined how glaciers affect the stability and...

In June 2019, a magnitude 4.0 earthquake occurred beneath Lake Erie just off the shoreline of Ohio, about 20 miles northeast of Cleveland.

Pervasive parasitic infections reduce herbivory rates and can therefore trigger trophic cascades that impact plant communities, according to new research. This work helps fill a recognized knowledge gap regarding the ecological consequences of parasitic infections in natural ecosystems.

Imagine a computer that can think as fast as the human brain while using very little energy. That's the goal of scientists seeking to discover or develop 'neuromorphic' materials that can send and process signals as easily as the brain's neurons and synapses. In a paper just published scientists describe surprising new details about vanadium dioxide, one of the most promising neuromorphic...

Researchers report that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain with no detectable side effects in mice with spinal cord or peripheral nerve injuries.

Researchers are teaching microscopes to drive discoveries with an intuitive algorithm that could guide breakthroughs in new materials for energy technologies, sensing and computing.

Women who experienced complications related to developing high blood pressure, or hypertension, during pregnancy had a 63% increased risk for developing cardiovascular disease later in life, according to new research.

Researchers have found that a suite of complimentary tests can quantify changes in dogs suspected of suffering from cognitive decline. The approach could not only aid owners in managing their elderly canine's care, but could also serve as a model for evaluating cognitive decline progression in -- and treatments for -- humans with Alzheimer's disease.

New research indicates that lethal collisions of whale sharks with large ships are vastly underestimated, and could be the reason why populations are falling.

Immunotherapy unleashes the power of the immune system to fight cancer. However, for some patients, immunotherapy doesn't work, and new research may help explain why. When immune cells called T lymphocytes infiltrate malignant tumors, the genetic program of those T cells and the developmental path they then follow, may affect their response to immunotherapy and predict overall patient survival,...

A tropical spider species uses a 'film' of air to hide underwater from predators for as long as 30 minutes, according to new research.

Researchers have devised a potentially easier way of gazing into the abyss. Their imaging technique could allow astronomers to study black holes smaller than M87's, a monster with a mass of 6.5 billion suns, harbored in galaxies more distant than M87, which at 55 million light-years away, is still relatively close to our own Milky Way.

Scientists used an unprecedented technique to detect that levels of helium are rising in the atmosphere, resolving an issue that has lingered among atmospheric chemists for decades.

Imagine being able to measure your blood sugar levels, know if you've had too much to drink, and track your fatigue during a workout, all in one small device worn on your skin. Engineers developed a prototype of such a wearable that continuously monitors several health stats at once.

The activation and inactivation mechanisms of a key protein involved in the circadian clock system of cyanobacteria -- an important organism in the evolution of such internal clocks -- have long eluded scientists. But researchers have now identified how the system is driven.