Researchers have discovered a novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, that successfully reprogrammed the tumor immune microenvironment (TIME) and significantly improved anti-tumor responses in preclinical models of pancreatic cancer.

New research takes a page from the field of renewable energy and shows that genetically engineered mitochondria can convert light energy into chemical energy that cells can use, ultimately extending the life of the roundworm C. elegans.

It is an exciting question why the internal clock runs almost unchanged at the same rate despite fluctuating temperatures. A team has now found an piece of the puzzle to answer this question.

Comparing models of working memory with real-world data, researchers found that information resides not in persistent neural activity, but in the pattern of their connections.

To find out how many scientists a region needs to become a leader in a discipline, researchers tracked millions of scientists moving across the globe. Their result: there is no critical mass, but you have to be a pioneer. Regions can catch up later, but this costs a lot.

A research team has shown that Sarunashi juice and its constituting component isoquercetin help prevent and reduce lung cancer in laboratory mice.

Language function and the psychosocial wellbeing of patients and their families can be promoted with singing-based rehabilitation. Group intervention provides opportunities for peer support while being simultaneously cost effective.

A team of engineers and neuroscientists has demonstrated for the first time that human brain organoids implanted in mice have established functional connectivity to the animals' cortex and responded to external sensory stimuli. The implanted organoids reacted to visual stimuli in the same way as surrounding tissues, an observation that researchers were able to make in real time over several months...

Researchers are bridging mouse and human data to reveal the biology of senescent cells. Senescent cells stop dividing in response to stressors and seemingly have a role to play in human health and the aging process. Recent research with mice suggests that clearing senescent cells delays the onset of age-related dysfunction and disease as well as all-cause mortality. 

A new paper presents a mathematical model for the motion of bacteria that includes cell division and death, the basic ingredients of the cell cycle.

Scientists have now been able to unravel a mystery surrounding the question of how cells use their sense of touch to make vital decisions during embryogenesis.

A new study reveals critical insights into the complex biology of tissue-specific T cells, paving the way for a new branch of precision therapeutics in immunity, autoimmunity, and cancer.

Researchers have found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung-resident alveolar macrophages (AMs). This interaction helps protect against viral infection and could form the basis for developing 'cell transplant'-type vaccines in the future.

Taking Hong Kong's famous Peak Tram up to Victoria Peak offers stunning views of its central business district, Victoria Harbor, and the surrounding islands. But a team of international scientists has recently discovered that the trams winding journey provides a previously unrecognized situation where our vertical perception gets distorted.

New insights into the opposing actions of serotonin-producing nerve fibers in mice could lead to drugs for treating addictions and major depression.

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a new study. The finding suggests that the enzyme may be a potential target for future cancer treatments.

A team of researchers has mapped the parts of the brain that support our ability to solve problems without prior experience -- otherwise known as fluid intelligence.

The biomarker, called 'brain-derived tau,' or BD-tau, outperforms current blood diagnostic tests used to detect Alzheimer's-related neurodegeneration clinically. It is specific to Alzheimer's disease and correlates well with Alzheimer's neurodegeneration biomarkers in the cerebrospinal fluid. Scientists hope that monitoring blood levels of BD-tau could facilitate screening and enrollment of...

For many people, holidays in the snow are as much a part of the end of the year as Christmas trees and fireworks. As global warming progresses, however, white slopes are becoming increasingly rare. Researchers have calculated how well one of Switzerland's largest ski resorts will remain snow reliable with technical snow-making by the year 2100, and how much water this snow will consume.

It was thought that there was only one species of the ghost-like Monotropastrum humile plant found in woodlands across East and Southeast Asia. In a major new discovery, botanists reveal that a rosy pink colored variant is actually a distinct new species, shaking up our understanding of this unusual-looking genus of plants. This 20-year study emphasizes the importance of combining various...

Scientists have found a way to improve the operational stability of perovskite solar cells, a crucial step towards their commercialization.

A quarter-sized device could drastically alter the course of treatment for Type 1 diabetes, a chronic condition that impacts millions of Americans and does not have a cure.

Researchers have found that microscopic ciliates can eat huge numbers of infectious chloroviruses that share their aquatic habitat. The team's lab experiments have also shown that a virus-only diet, which the team calls 'virovory,' is enough to fuel the physiological growth and even population growth of an organism.

A research group has revealed that the checkerboard-like arrangement of cells in the inner ear's organ of Corti is vital for hearing. The discovery gives a new insight into how hearing works from the perspective of cell self-organization and will also enable various hearing loss disorders to be better understood.