103 articles from TUESDAY 3.1.2023

Age-related macular degeneration a risk factor for COVID-19 infection, severe disease

Researchers hypothesized that AMD and COVID-19 share common genetic risk factors and carried out a study that identified a novel association of the two diseases with variants in the PDGFB gene. This gene encodes a platelet derived growth factor (Pdgf) which has a role in the formation of new blood vessels and is involved in the abnormal blood vessel changes that occur in AMD. They also found that...

COVID-19 vaccine for children after MIS-C appears safe

A study of children and adolescents who received a COVID-19 vaccination following multisystem inflammatory syndrome (MIS-C) found that there were no reports of serious complications including myocarditis or MIS-C reoccurrence. About half of participants experienced mild and typical reactions, including arm soreness and fatigue. The study demonstrates that it is safe to get a vaccine after having...

Microprotein increases appetite in mice

Scientists have discovered that both brown and white fat is filled with thousands of previously unknown microproteins, and show that one of these microproteins, called Gm8773, can increase appetite in mice. These findings could lead to the development of a therapeutic to help people gain weight in certain disease situations, such as during chemotherapy for cancer.

Time-restricted eating reshapes gene expression throughout the body

Scientists show in mice how time-restricted eating influences gene expression across more than 22 regions of the body and brain. The findings have implications for a wide range of health conditions where time-restricted eating has shown potential benefits, including diabetes, heart disease, hypertension, and cancer.

Tracking radiation treatment in real time promises safer, more effective cancer therapy

Radiation, used to treat half of all cancer patients, can be measured during treatment for the first time with precise 3D imaging. By capturing and amplifying tiny sound waves created when X-rays heat tissues in the body, medical professionals can map the radiation dose within the body, giving them new data to guide treatments in real time. It's a first-of-its-kind view of an interaction doctors...

Fewer moths, more flies

In the far north of the planet, climate change is clearly noticeable. A new study now shows that in parallel there have been dramatic changes in pollinating insects. Researchers have discovered that the network of plants and their pollinators there has changed considerably since the end of the 19th century. Scientists warn this could lead to plants being pollinated less effectively. This, in turn,...

Declining trend in the use of antibiotics in fattening animals

Antibiotics are being used less and less in fattening animals. This is the result found by the report, "Treatment Frequency and Antibiotic Consumption Quantities 2018–2021: Trends in Cattle, Pigs, Chickens and Turkeys Kept for Meat Production," by the German Federal Institute for Risk Assessment (BfR). The BfR is tasked with evaluating the data on antibiotic use provided by the German federal...

Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2

ABC transporters constitute a major class of multidrug resistance proteins, e.g., in cancer cells. Membrane lipids have been long known to influence the structure and functional dynamics of these proteins. However, previous structural and biochemical studies on ABCG2 are limited either by their static description or low spatial resolution to provide a microscopic view of the dynamics of the drug...

Cells found to possess two mechanisms that allow them to respond to different force ranges

A study carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) heralds a paradigm change in the field of mechanobiology. The study reveals that cells respond to forces of differing strength using use two distinct mechanisms, one mediated by minute, cup-like invaginations on the cell surface called caveolae and the other by newly discovered large membrane depressions the...

Knife that ‘smells tumours’ can detect womb cancer within seconds

Exclusive: iKnife can reliably diagnose endometrial cancer and help thousands of healthy women get all-clear quickerA revolutionary surgical knife that “smells tumours” can diagnose womb cancer within seconds, researchers have found in a breakthrough that could enable thousands of healthy women to get the all-clear quicker.The disease is the fourth most common cancer in women and affects about...

New role of small RNAs in Salmonella infections uncovered

Salmonella are food-borne pathogens that infect millions of people each year. To do so, these bacteria depend on a complex network of genes and gene products that allow them to sense environmental conditions. In a new paper, researchers have investigated the role of small RNAs that help Salmonella express their virulence genes.

Harnessing tumor's power to heal non-healing wounds

Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells—but for a good purpose—to accelerate diabetic wound healing. This remarkably promising finding, recently published in EMBO Molecular Medicine, may open up a brand new avenue for regenerative medicine.