29 articles from SUNDAY 12.11.2023

Base editing, a new form of gene therapy, sharply lowers bad cholesterol in clinical trial

A technique for precisely rewriting the genetic code directly in the body has slashed “bad” cholesterol levels—possibly for life—in three people prone to dangerously high levels of the artery-clogging fat. The feat relied on a blood infusion of a so-called base editor, designed to disable a liver protein, PCSK9, that regulates cholesterol. “It is a breakthrough to have...

57 years ago, two astronauts saw the first solar eclipse from space

On Nov. 12, 1966, totality sliced across South America. Its progress began north of Peru’s capital, Lima, before forging a 52-mile-wide (84 kilometers) southeasterly swath of totality to plunge northern Chile and Bolivia, the foothills of northwestern Argentina and Paraguay’s rural southwest, and almost as far as the southern tip of Brazil, into an etherealContinue reading "57 years ago, two...

The openness of talking to strangers – and the intimate stories they share

The stories people tell me about their lives can be funny, surprising, tragic or shocking – and some stay with me for yearsI can distinctly remember being in the back seat of the family car on a long journey (to Devon probably – that drive felt interminable), looking at all the other cars full of people and thinking, “Where on earth are they all going and why?” As my eyes went funny trying...

How digital twins may enable personalised health treatment

Research is growing into computational models that will move medicine beyond what works on the average patientImagine having a digital twin that gets ill, and can be experimented on to identify the best possible treatment, without you having to go near a pill or a surgeon’s knife. Scientists believe that within five to 10 years, “in silico” trials – in which hundreds of virtual organs are...

How researchers, farmers and brewers want to safeguard beer against climate change

On a bright day this fall, tractors crisscrossed Gayle Goschie's farm about an hour outside Portland, Oregon. Goschie is in the beer business—a fourth-generation hops farmer. Fall is the off-season, when the trellises are bare, but recently, her farming team has been adding winter barley, a relatively newer crop in the world of beer, to their rotation, preparing barley seeds by the bucketful.

‘Violent colonialist’ Magellan is unfit to keep his place in the night sky, say astronomers

Indigenous peoples already had their own names for the galaxies named after the 16th-century Portuguese explorerFor centuries Ferdinand Magellan has been accorded a rare privilege. The explorer’s name has been written in the stars. Two satellite galaxies of our own Milky Way, which sparkle conspicuously over the southern hemisphere, are labelled the Large and Small Magellanic Clouds.Now...

Floating factories of artificial leaves could make green fuel for jets and ships

Cambridge University scientists develop a device to ‘defossilise’ the economy using sunlight, water and carbon dioxideAutomated floating factories that manufacture green versions of petrol or diesel could soon be in operation thanks to pioneering work at the University of Cambridge. The revolutionary system would produce a net-zero fuel that would burn without creating fossil-derived emissions...