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163,091 articles from EurekAlert

Addition of sintilimab to pemetrexed and platinum improved progression-free survival

The interim analysis of ORIENT-11, a phase III double-blind randomized trial has shown a nearly two-fold increase in progression-free survival with addition of sintilimab to chemotherapy in patients with advanced or metastatic non-squamous non-small cell lung cancer without EGFR or ALK genomic aberrations, according to research data presented today at the International Association for the Study of...

checkmate 743 shows that dual immunotherapy, nivolumab + ipilimumab

The combination of first-line nivolumab and ipilimumab demonstrated an improvement of overall survival for patients with unresectable malignant pleural mesothelioma compared to platinum-based chemotherapy, according to research presented today at the International Association for the Study of Lung Cancer Virtual Presidential Symposium.


FRIDAY 7. AUGUST 2020


A titanate nanowire mask that can eliminate pathogens

Researchers in Lásló Forró's lab at EPFL, Switzerland, are working on a membrane made of titanium oxide nanowires, similar in appearance to filter paper but with antibacterial and antiviral properties. Their material works by using the photocatalytic properties of titanium dioxide: when exposed to ultraviolet radiation, the fibers convert resident moisture into oxidizing agents such as...

Adding another dimension to a cell culture model for pulmonary arterial hypertension

Pulmonary arterial hypertension is a rare disease in which excessive proliferation of the cells of pulmonary arterial walls obstructs the blood flow in the lungs. A group of scientists based in Okayama, Japan, has now used 3D cell culture technology to recapitulate the pathogenetic process involved in pulmonary arterial hypertension in the laboratory, with potential applications in drug testing.

Advance in programmable synthetic materials

DNA information is stored in a sequence of chemical building blocks; computers store information as sequences of zeros and ones. Researchers want to transfer this concept to artificial molecules. UC Berkeley and Ruhr-Universität Bochum researchers have taken another step toward encoding information in the sequence of metal atoms in metal-organic frameworks (MOFs), showing how to read the...

COVID recovery choices shape future climate

A new international study, led by the University of Leeds, warns that even with some lockdown measures staying in place to the end of 2021, without more structural interventions global temperatures will only be roughly 0.01°C lower than expected by 2030. However, the study estimates that including climate policy measures as part of an economic recovery plan with strong green stimulus could...

COVID-19 - The virus and the vasculature

In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

Experts urge evaluation of diet at routine check-ups

Unhealthy dietary patterns are a leading cause of heart disease and stroke as well as other chronic diseases.Clinician-delivered diet counseling can improve diet behaviors and heart disease risk factors.Quick, simple dietary assessment tools can be a part of routine office visits and integrated into electronic health records for follow-up.

Genetic cause of congenital malformation discovered

Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia. This is shown in an international study led by the University of Bonn and published in the journal "Frontiers in Cell and Developmental Biology". The researchers also owe their findings to an unusual model organism: the zebrafish.

Highly sensitive dopamine detector uses 2D materials

A supersensitive dopamine detector can help in the early diagnosis of several disorders that result in too much or too little dopamine, according to a group led by Penn State and including Rensselaer Polytechnic Institute and universities in China and Japan.

Hubble makes the first observation of a total lunar eclipse by a space telescope

Taking advantage of a total lunar eclipse, astronomers using the NASA/ESA Hubble Space Telescope have detected ozone in Earth's atmosphere. This method serves as a proxy for how they will observe Earth-like planets around other stars in the search for life. This is the first time a total lunar eclipse was captured from a space telescope and the first time such an eclipse has been studied in...

Huge ring-like structure on Ganymede's surface may have been caused by violent impact

Image data reanalysis by researchers from Kobe University and the National Institute of Technology, Oshima College have revealed that ancient tectonic troughs are concentrically distributed across almost the entire surface of Ganymede. Computer simulation results suggest that this giant crater could have resulted from the impact of an asteroid with a 150km radius. If so, this the largest impact...