The interim analysis of ORIENT-11, a phase III double-blind randomized trial has shown a nearly two-fold increase in progression-free survival with addition of sintilimab to chemotherapy in patients with advanced or metastatic non-squamous non-small cell lung cancer without EGFR or ALK genomic aberrations, according to research data presented today at the International Association for the Study of...

The combination of first-line nivolumab and ipilimumab demonstrated an improvement of overall survival for patients with unresectable malignant pleural mesothelioma compared to platinum-based chemotherapy, according to research presented today at the International Association for the Study of Lung Cancer Virtual Presidential Symposium.

Patients with non-small cell lung cancer (NSCLC) carrying anaplastic lymphoma kinase (ALK) gene alterations who received ensartinib experienced substantially longer progression-free survival than a matched group of patients who received crizotinib.

Researchers in Lásló Forró's lab at EPFL, Switzerland, are working on a membrane made of titanium oxide nanowires, similar in appearance to filter paper but with antibacterial and antiviral properties. Their material works by using the photocatalytic properties of titanium dioxide: when exposed to ultraviolet radiation, the fibers convert resident moisture into oxidizing agents such as...

Pulmonary arterial hypertension is a rare disease in which excessive proliferation of the cells of pulmonary arterial walls obstructs the blood flow in the lungs. A group of scientists based in Okayama, Japan, has now used 3D cell culture technology to recapitulate the pathogenetic process involved in pulmonary arterial hypertension in the laboratory, with potential applications in drug testing.

DNA information is stored in a sequence of chemical building blocks; computers store information as sequences of zeros and ones. Researchers want to transfer this concept to artificial molecules. UC Berkeley and Ruhr-Universität Bochum researchers have taken another step toward encoding information in the sequence of metal atoms in metal-organic frameworks (MOFs), showing how to read the...

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed for the first time in the world that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

The "invisible" words that shaped Dickens classics also lead audiences through Spielberg dramas. And according to new research, these small words can be found in a similar pattern across most storylines, no matter the length or format.

A patient-specific tumor organoid model developed at Wake Forest is being used to identify the most effective chemotherapy protocol to treat appendix and colon tumors, a personalized medicine approach that is showing promise.

A new international study, led by the University of Leeds, warns that even with some lockdown measures staying in place to the end of 2021, without more structural interventions global temperatures will only be roughly 0.01°C lower than expected by 2030. However, the study estimates that including climate policy measures as part of an economic recovery plan with strong green stimulus could...

In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

Dr Steven Truxal, an aviation law expert in The City Law School, says state aid offered to airlines in response to the current crisis raises questions around unfair competition between European carriers and may be the subject of future challenge by carriers outside the EU.

By applying the renewal theory in probability to reduce recall bias in initial case reports, scientists have come up with a new estimate for the incubation period of COVID-19. Their mean estimate of 7.76 days.

A team of scientists led by Kate Evans, a Washington State University horticulture professor who leads WSU's pome fruit (apples and pears) breeding program, found that public plant breeding programs are seeing decreases in funding and personnel.

A new publication on the impacts of deep-seabed mining by 13 prominent deep-sea biologists, led by University of Hawai'i at Mānoa, seeks to dispel scientific misconceptions that have led to miscalculations of the likely effects of commercial operations to extract minerals from the seabed.

This survey study of US physicians examined whether there were differences by race/ethnicity in burnout, symptoms of depression, career satisfaction and work-life balance.

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

Unhealthy dietary patterns are a leading cause of heart disease and stroke as well as other chronic diseases.Clinician-delivered diet counseling can improve diet behaviors and heart disease risk factors.Quick, simple dietary assessment tools can be a part of routine office visits and integrated into electronic health records for follow-up.

A key component of the Gulf Stream has markedly slowed over the past century--that's the conclusion of a new research paper in Nature Communications published on August 7, 2020.

Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia. This is shown in an international study led by the University of Bonn and published in the journal "Frontiers in Cell and Developmental Biology". The researchers also owe their findings to an unusual model organism: the zebrafish.

The increases and decreases in patient volume and associated changes in treatment experienced by individuals presenting with acute heart attack (myocardial infarction) before and immediately after the onset of the COVID-19 pandemic are examined in this observational study.

Each cigarette smoked a day by heavier smokers increases the risk of contracting some diseases by more than 30 per cent, according to a new international study published today.

A supersensitive dopamine detector can help in the early diagnosis of several disorders that result in too much or too little dopamine, according to a group led by Penn State and including Rensselaer Polytechnic Institute and universities in China and Japan.

Taking advantage of a total lunar eclipse, astronomers using the NASA/ESA Hubble Space Telescope have detected ozone in Earth's atmosphere. This method serves as a proxy for how they will observe Earth-like planets around other stars in the search for life. This is the first time a total lunar eclipse was captured from a space telescope and the first time such an eclipse has been studied in...