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183,128 articles from EurekAlert

High blood pressure in older adults traced to gene's effects in blood vessels

Scientists have identified the gene that sets off a sequence of events in the blood vessels of otherwise healthy adults that can lead to high blood pressure. The disease process eventually makes conditions in vessels ripe for the creation of blockages that can cause heart attacks, strokes and circulatory problems. The finding might lead to new therapeutic options for high blood pressure,...

Hubble finds double Einstein ring

The NASA/ESA Hubble Space Telescope has revealed a never-before-seen optical alignment in space: a pair of glowing rings, one nestled inside the other like a bull's-eye pattern. The double-ring pattern is caused by the complex bending of light from two distant galaxies strung directly behind a foreground massive galaxy, like three beads on a string.

JCI online early table of contents: Jan. 10 2008

This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Jan. 10, 2008, in the JCI, including: A new way to boost red blood cell numbers; A PIN(1) prick for lung scarring: inhibiting PIN1 reduces rodent lung scarring; The protein myocardin helps plug the ductus arteriosus; Understanding how carbon dioxide can impair lung...

Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread

A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that...

Memantine and Alzheimer's disease

In a study published in the Journal of Alzheimer's Disease, researchers from the University of Aberdeen report that the drug memantine, used for the treatment of Alzheimer's disease and praised as "the first and only representative of a new class of Alzheimer drugs" works in fact similar to other existing compounds, and is beneficial only in a narrow concentration range. They further indicate that...

Nanotechnology innovation may revolutionize gene detection in a single cell

Scientists at Arizona State University's Biodesign Institute have developed the world’s first gene detection platform made up entirely from self-assembled DNA nanostructures. The results, appearing in the Jan. 11 issue of the journal Science, could have broad implications for gene chip technology and may also revolutionize the way in which gene expression is analyzed in a single cell.

NASA scientists predict black hole light echo show

It's well known that black holes can slow time to a crawl and tidally stretch large objects into spaghetti-like strands. But according to new theoretical research from two NASA astrophysicists, the wrenching gravity just outside the outer boundary of a black hole can produce yet another bizarre effect: light echoes.

New picture of HIV-1's protein jacket identifies target for antibody-based vaccine

By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber Cancer Institute and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection. The discovery may provide scientists with an attractive target for antibody-based vaccine.

New research demonstrates potential diagnosis, treatment benefits

Studies published in the Jan. 10 edition of the New England Journal of Medicine are providing clues into the treatment and diagnosis of LAM, or lymphangioleiomyomatosis, a progressive and deadly lung disease that affects women in their childbearing years. There currently are no treatments for LAM and scientists estimate as many as 250,000 women may be going misdiagnosed or undiagnosed.

Overactive nerves in head and neck may account for 'ringing in the ears'

Baby boomers know all too well that "ringing in the ears" often comes with aging and hearing loss. Tinnitus can be the buzz that somatosensory neurons from the head and neck, like too many phone callers, create when they overcompensate for lost auditory signals from the ear, an animal study suggests. This nimble response to hearing loss, in which neurons adapt to changed conditions, is an example...

Pediatricians call for a cohesive definition of metabolic syndrome in children

Metabolic syndrome is a group of cardiovascular risk factors, including obesity, hypertension, prediabetes, and reduced HDL ("good") cholesterol. Because it is difficult to know when a child is at risk for metabolic syndrome, some doctors fear that children may not be properly diagnosed as a result. The February 2008 issue of The Journal of Pediatrics focuses on this issue by publishing a series...

Physicists uncover new solution for cosmic collisions

It turns out that our math teachers were right: being able to solve problems without a calculator does come in handy in the "real" world. Two theoretical physicists at Rensselaer Polytechnic Institute have used what they call "pen-and-paper math" to describe the motion of interstellar shock waves -- violent events associated with the birth of stars and planets.

Researchers challenge previous findings regarding widely used asthma treatment

A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype, as previous studies had shown. The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific...

Researchers move 2 steps closer to understanding genetic underpinnings of autism

Today's issue of the American Journal of Human Genetics, describes what might be a corner piece of the autism puzzle -- the identification and subsequent validation of a gene linked to the development of autism by three separate groups of scientists. An accompanying commentary by Dr. Dietrich Stephan, Director of the Neurogenomics Division at the Translational Genomics Research Institute, further...