Genetic breakthrough offers promise in tackling kidney tumors
183,128 articles from EurekAlert
Genomic screen nets hundreds of human proteins exploited by HIV
Early tests show promising results for a new treatment for tuberous sclerosis, which can cause tumors in organs throughout the body. The UK study is led by Cardiff University's Institute of Medical Genetics, which was the first to identify the genes linked to the disease.
High blood pressure in older adults traced to gene's effects in blood vessels
Using a technique called RNA interference to screen thousands of genes, researchers identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies.
Hubble finds double Einstein ring
Scientists have identified the gene that sets off a sequence of events in the blood vessels of otherwise healthy adults that can lead to high blood pressure. The disease process eventually makes conditions in vessels ripe for the creation of blockages that can cause heart attacks, strokes and circulatory problems. The finding might lead to new therapeutic options for high blood pressure,...
JCI online early table of contents: Jan. 10 2008
The NASA/ESA Hubble Space Telescope has revealed a never-before-seen optical alignment in space: a pair of glowing rings, one nestled inside the other like a bull's-eye pattern. The double-ring pattern is caused by the complex bending of light from two distant galaxies strung directly behind a foreground massive galaxy, like three beads on a string.
Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Jan. 10, 2008, in the JCI, including: A new way to boost red blood cell numbers; A PIN(1) prick for lung scarring: inhibiting PIN1 reduces rodent lung scarring; The protein myocardin helps plug the ductus arteriosus; Understanding how carbon dioxide can impair lung...
Lasting impression: Does the face of a CEO determine a successful company?
A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that...
Memantine and Alzheimer's disease
It certainly takes more than a pretty face to run a leading national corporation. But according to a recent Tufts University study, the performance levels of America's top companies could be related to the first impressions made by their chief executive officers.
Nanotechnology innovation may revolutionize gene detection in a single cell
In a study published in the Journal of Alzheimer's Disease, researchers from the University of Aberdeen report that the drug memantine, used for the treatment of Alzheimer's disease and praised as "the first and only representative of a new class of Alzheimer drugs" works in fact similar to other existing compounds, and is beneficial only in a narrow concentration range. They further indicate that...
NASA scientists predict black hole light echo show
Scientists at Arizona State University's Biodesign Institute have developed the worlds first gene detection platform made up entirely from self-assembled DNA nanostructures. The results, appearing in the Jan. 11 issue of the journal Science, could have broad implications for gene chip technology and may also revolutionize the way in which gene expression is analyzed in a single cell.
New picture of HIV-1's protein jacket identifies target for antibody-based vaccine
It's well known that black holes can slow time to a crawl and tidally stretch large objects into spaghetti-like strands. But according to new theoretical research from two NASA astrophysicists, the wrenching gravity just outside the outer boundary of a black hole can produce yet another bizarre effect: light echoes.
New research demonstrates potential diagnosis, treatment benefits
By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber Cancer Institute and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection. The discovery may provide scientists with an attractive target for antibody-based vaccine.
Older Arctic sea ice replaced by young, thin ice, says CU-Boulder study
Studies published in the Jan. 10 edition of the New England Journal of Medicine are providing clues into the treatment and diagnosis of LAM, or lymphangioleiomyomatosis, a progressive and deadly lung disease that affects women in their childbearing years. There currently are no treatments for LAM and scientists estimate as many as 250,000 women may be going misdiagnosed or undiagnosed.
Overactive nerves in head and neck may account for 'ringing in the ears'
A new study by University of Colorado at Boulder researchers indicates older, multiyear sea ice in the Arctic is giving way to younger, thinner ice, making it more susceptible to record summer sea-ice lows like the one that occurred in 2007.
Pediatricians call for a cohesive definition of metabolic syndrome in children
Baby boomers know all too well that "ringing in the ears" often comes with aging and hearing loss. Tinnitus can be the buzz that somatosensory neurons from the head and neck, like too many phone callers, create when they overcompensate for lost auditory signals from the ear, an animal study suggests. This nimble response to hearing loss, in which neurons adapt to changed conditions, is an example...
People with dementia survive on average four and a half years after diagnosis
Metabolic syndrome is a group of cardiovascular risk factors, including obesity, hypertension, prediabetes, and reduced HDL ("good") cholesterol. Because it is difficult to know when a child is at risk for metabolic syndrome, some doctors fear that children may not be properly diagnosed as a result. The February 2008 issue of The Journal of Pediatrics focuses on this issue by publishing a series...
Physicists uncover new solution for cosmic collisions
People with dementia survive an average of four and a half years after diagnosis, with age, sex and existing disability all having an influence on life expectancy, finds a study published online today.
Protein in human hair shows promise for regenerating nerves
It turns out that our math teachers were right: being able to solve problems without a calculator does come in handy in the "real" world. Two theoretical physicists at Rensselaer Polytechnic Institute have used what they call "pen-and-paper math" to describe the motion of interstellar shock waves -- violent events associated with the birth of stars and planets.
Researchers challenge previous findings regarding widely used asthma treatment
A protein found in human hair shows promise for promoting the regeneration of nerve tissue and could lead to a new treatment option when nerves are cut or crushed from trauma.
Researchers move 2 steps closer to understanding genetic underpinnings of autism
A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype, as previous studies had shown. The study analyzed the effects of long-acting beta-agonist therapy, used in combination with inhaled corticosteroids, in asthmatics who have a specific...
Researchers shed light on genetic factors behind UK's biggest killer
Today's issue of the American Journal of Human Genetics, describes what might be a corner piece of the autism puzzle -- the identification and subsequent validation of a gene linked to the development of autism by three separate groups of scientists. An accompanying commentary by Dr. Dietrich Stephan, Director of the Neurogenomics Division at the Translational Genomics Research Institute, further...
SAGE's American Journal of Lifestyle Medicine looks at the health benefit of oats
Researchers have discovered a new chromosomal region to be strongly associated with bad cholesterol -- a major cause of coronary heart disease. The finding could pave the way towards new therapies for the diease.
Scientists map out potential for restoring California fisher populations
SAGE is pleased to announce that American Journal of Lifestyle Medicine is kicking off its second year of publication by publishing research about a key component of a heart healthy diet.
Should heroin be prescribed to addicts?
US Forest Service and U.C. Santa Barbara scientists believe they have identified the habitat needs for Pacific fishers, a rare California mammal that is a candidate for reintroduction efforts and listing under the Endangered Species Act. Their findings were published in the current edition of Ecological Applications.
Simple test accurately predicts risk of serious jaundice in newborns
In this week's BMJ experts debate whether heroin should be prescribed to addicts who are difficult to treat.
A simple test can accurately identify which newborn babies are at risk for developing dangerous levels of jaundice, according to researchers at the Children's Hospital of Philadelphia.