912,143 articles

Eating less keeps the brain young

Overeating may cause brain aging while eating less turns on a molecule that helps the brain stay young.A team of Italian researchers at the Catholic University of Sacred Heart in Rome have discovered that this molecule, called CREB1, is triggered by "caloric restriction" in the brain of mice. They found that CREB1 activates many genes linked to longevity and to the proper functioning of the brain.

First aid after tick bites

They come out in the spring, and each year they spread further - the ticks. Thirty percent of them transmit borrelia pathogens, the causative agent of Lyme borreliosis that can damage joints and organs. The disease often goes undetected. In the future, a new type of gel is intended to prevent an infection - if applied after a tick bite.

Georgetown researchers lead discovery expected to significantly change biomedical research

In a major step that could revolutionize biomedical research, scientists have discovered a way to keep normal cells as well as tumor cells taken from an individual cancer patient alive in the laboratory -- which previously had not been possible. Normal cells usually die in the lab after dividing only a few times, and many common cancers will not grow, unaltered, outside of the body.

German research team targets 'at risk' data on biodiversity

A new German-based project is setting out to rescue biodiversity data at risk of being lost, because they are not integrated in institutional databases, are kept in outdated digital storage systems, or are not properly documented.The project, run by the Botanic Garden and Botanical Museum Berlin-Dahlem, provides a good example for a GBIF recommendation to establish hosting centers for biodiversity...

Grafting of human spinal stem cells into ALS rats best with immunosuppressant combination

Researchers grafting human spinal stem cells into rats modeled with amyotrophic lateral sclerosis (ALS) tested four immunosuppressive protocols to determine which regimen improved long-term therapeutic effects. Combined, systematically delivered immunosuppression regimens of tacrolimus (FK506) and mycophenolate significantly improved the survival of transplanted human spinal stem cells. While the...

Hedge fund share restrictions favor managers over investors

A new study of hedge fund managers' trading habits shows they sell off their holdings ahead of other investors. The motivation, the researchers say, is a predictable drop in fund performance after investors pull out of share-restricted funds. The authors say private information about a fund -- particularly the flow of investment dollars -- may constitute material information.

Hospitals invest heavily in new heart attack care programs but fail to improve access

Researchers have found a 44 percent increase since 2001 in the number of hospitals that offer definitive emergency care to patients with heart attack, but only a one percent increase in access to that care. The study, led by Thomas W. Concannon, PhD, Assistant Professor Tufts Medical Center and Tufts University School of Medicine, will be published Jan. 1, 2012 in Circulation: Cardiovascular...

Infrared technology for measuring the effect of fire on materials

Researchers at Universidad Carlos III de Madrid are developing an infrared measuring method to analyze the thermal properties and resistance to fire of composite materials. This advance would have applications in aerospace engineering and other areas where fire safety requires that the "composite" materials withstand high temperatures.

JCI online early table of contents: Dec. 19, 2011

This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Dec. 19, 2011, in the JCI: Potential concern about drugs in clinical trial; Blood pressure drug limits cigarette smoke-induced lung injury in mice; A full TANC(1) needed to drive rhabdomyosarcoma; Growth factor link to breast cancer; Heparan sulfate: protecting the...

Knee pain common complaint in middle-aged and mature women

New research shows 63 percent of women age 50 and older reported persistent, incident, or intermittent knee pain during a 12-year study period. Predictors for persistent pain included higher body mass index, previous knee injury, and radiographic osteoarthritis. Details of this longitudinal study are available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the...

Legumes give nitrogen-supplying bacteria special access pass

A 125-year debate on how nitrogen-fixing bacteria are able to breach the cell walls of legumes has been settled. A paper to be published on Monday by John Innes Centre scientists reports that plants themselves allow bacteria in. The fact that legumes themselves call the shots is a great finding but it also shows the complexity of the challenge to try to transfer the process to non-legumes.

Lower classes quicker to show compassion in the face of suffering

Emotional differences between the rich and poor, as depicted in such Charles Dickens classics as "A Christmas Carol" and "A Tale of Two Cities," may have a scientific basis. Researchers at the University of California, Berkeley, have found that people in the lower socio-economic classes are more physiologically attuned to suffering, and quicker to express compassion than their more affluent...

Middle-age blood pressure changes affect lifetime heart disease, stroke risk

Changes in blood pressure during middle age can affect lifetime risk for heart disease and stroke. People who maintain or reduce their blood pressure to normal levels during middle age have the lowest lifetime risk of cardiovascular disease, while those with an increase in blood pressure have the highest risk. Age and duration of blood pressure changes can help determine individualized lifetime...

MU researchers find pet kidney injuries are similar to human kidney injuries

For pets suffering critical illness or injury, University of Missouri researchers have found that even tiny increases of creatinine in blood also could indicate acute kidney damage. Using human blood measurement guidelines for acute kidney injuries, the researchers believe they can now help pet owners better know the severity of their animals' illness.