817,254 articles

Engineered human fusion protein inhibits HIV-1 replication

Fusion protein AoT5Cyp blocks HIV-1 infection in owl monkeys. The human genome encodes the equivalent of the 2 components of AoT5Cyp (TRIM5 and cyclophilin A), but humans unfortunately do not make the fusion protein. Researchers have now fused human cyclophilin A and TRIM5 and this protein inhibited HIV-1 replication in human macrophages, T cells and mice engrafted with human CD4+ T cells...

Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein

Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking how enzymes are naturally regulated within cells.

Even In A Safety Net Health System, Colorectal Cancer Screening Disparities Remain

Colorectal cancer screening rates are much lower among those in a safety net health system compared to the national average, and the number one predictor of screening is a combination of regular visits and insurance access. However, results of a recent study showed that the screening rate was merely 22 percent among individuals served by a safety net health system in...

Face processing slows with age

Identifying a face can be difficult when that face is shown for only a fraction of a second. However, young adults have a marked advantage over elderly people in these conditions. Researchers writing in the open-access journal BMC Neuroscience found indications that elderly people have reduced perception speed.

Flips, flops and cartwheels

Researchers from University of Calgary and Clemson University have analyzed the complex movement patterns of geckos' tails after they separate from the body in a paper they co-authored published in the journal Biology Letters.

High fruit and vegetable intake positively correlated with antioxidant status, cognitive performance

Researchers at the Institute of Biochemistry and Molecular Biology I of the Heinrich-Heine University, Duesseldorf, Germany, investigated the relationship between fruit and vegetable intake, plasma antioxidant micronutrient status and cognitive performance in healthy subjects aged 45 to 102 years. Their results, published in the August issue of the Journal of Alzheimer's Disease, indicated higher...

Houseplants Cut Indoor Ozone

Ozone, the main component of air pollution, or smog is most often associated with outdoor air but it also infiltrates indoor environments like homes and offices and with people in industrialized countries spending as much of 80 percent to 90 percent of their time indoors, eliminating ozone is a health priority. University researchers studied the effects of three common houseplants on reducing...

Houseplants cut indoor ozone

Ozone, the main component of air pollution, or smog is most often associated with outdoor air but it also infiltrates indoor environments like homes and offices and with people in industrialized countries spending as much of 80 percent to 90 percent of their time indoors, eliminating ozone is a health priority. University researchers studied the effects of three common houseplants on reducing...

How do doctors really feel about surrogate decision making?

A study published in the September 2009 issue of the Journal of General Internal Medicine found that one in five doctors are not comfortable working with a surrogate decision maker. The doctors surveyed reported ineffective communication, lack of satisfaction with the outcome of the decision, and an increase in stress level as a result of the surrogate decision making process.

JCI online early table of contents: Sept. 8, 2009

This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Sept. 8, 2009, in the JCI, including: Engineered human fusion protein protects against HIV-1 infection; TNF-alpha promotes ovarian tumors with a little help from friends TNFR1 and IL-17; Cdc42 restrains hypertrophy in the heart; and Kinase CAMKII links multiple...

JDRF-funded studies show regular CGM use increases diabetes control for all age groups

The latest data from groundbreaking human clinical trials of the effectiveness of continuous glucose monitors show that the primary determinant of improvements in achieving better diabetes control is regular use of monitors -- six days per week or more -- rather than the age of patients, and that benefits continue well past the time when people with type 1 diabetes begin using the devices --...

K-12 education should include engineering

The introduction of K-12 engineering education has the potential to improve student learning and achievement in science and mathematics, increase awareness about what engineers do and of engineering as a potential career and boost students' technological literacy, according to a new report from the National Academy of Engineering and the National Research Council.

Lapatinib shows minimal effect against liver cancer

Use of the molecularly targeted agent lapatinib to delay tumor growth and improve the survival of patients with inoperable hepatocellular carcinoma, or liver cancer, only benefited certain subgroups of patients. While results of this study were largely negative, patients that exhibited toxicity from the drug in the form of a skin rash appeared to have a greater tumor response and longer survival.