866,127 articles

Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?

Lansoprazole is a proton pump inhibitor which powerfully suppresses gastric acid production and is widely prescribed for chronic use in gastroesophageal reflux disease. Lansoprazole uncommonly causes chronic watery diarrhea unresponsive to conventional medication as a symptom of collagenous colitis. This association has recently been reported and is not widely known. Correct diagnosis and...

Climate change driving Michigan mammals north

Some Michigan mammal species are rapidly expanding their ranges northward, apparently in response to climate change, a new study shows. In the process, these historically southern species are replacing their northern counterparts.

Enriched environment improves wound healing in rats

Improving the environment in which rats are reared can significantly strengthen the physiological process of wound healing, according to a report in the open-access journal PLoS ONE. Researchers from the Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital and Shriners Burns Hospital found that giving rats living in isolation the opportunity to build nests led to better...

Farnesoid X receptor regulates cystathionase

Farnesoid X receptor is a member of the ligand-activated nuclear hormone receptor superfamily. It functions as heterodimer with retinoid X receptor and binds genomic DNA of the target genes promoters containing an inverted repeat sequence in which consensus receptor-binding hexamers are separated by one nucleotide. Cystathionase catalyzes essential steps in the trans-sulfuration pathway that leads...

Following the leader: Social networks of schoolchildren

Kids always seem to be ahead of trends, and marketers realize the importance of new products and services taking off with the younger set. A new study in the Journal of Consumer Research helps identify which children might be the trendsetters of their generation.

How to build a bigger brain

UCLA researchers report that certain regions of the brain in long-term meditators were larger than non-meditators. Specifically, meditators showed significantly larger volumes of the hippocampus, and within the orbito-frontal cortex, thalamus and inferior temporal gyrus, all regions of the brain known for regulating emotions.

Hyperferritinemia is another surrogate marker of advanced liver disease

High serum ferritin, being a hallmark of hereditary hemochromatosis , is frequently found in chronic hepatitis C, alcoholic or non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients . A study in Italy has investigated the link between ferritin and steatosis in a non-obese cohort of non-alcoholic patients. In southern European populations, high ferritin levels, after exclusion...

Improving education may cut smoking in youth

Although low socioeconomic status is associated with an increased liability to smoke, performing well at school can mitigate this effect. A new study, published in BioMed Central's open-access International Journal for Equity in Health, has shown that high-achieving schoolchildren, even those from poor backgrounds, are less likely to smoke.

In retinal disease, sight may depend on second sites

If two people have the same genetic disease, why would one person go blind in childhood but the other later in life or not at all? For a group of genetic diseases -- so-called ciliary diseases that include Bardet-Biedl syndrome, Meckel-Gruber syndrome and Joubert syndrome -- the answer lies in one gene that is already linked to two of these diseases and also seems to increase the risk of...

Interventional radiology: From sidelines to mainstream for patients

The Society of Interventional Radiology hailed the extension of an American College of Radiology resolution in support of clinical patient management by vascular and interventional radiologists as an important reminder of the critical contribution these minimally invasive specialists bring to quality patient health care.

JNCI May 12 issue tip sheet

In addition to the study highlighted in the press release, this JNCI issue includes a review of traditional and updated phase I trial designs; a study and editorial examining lymphovascular invasion and high risk breast cancer; data showing how four immunohistochemistry tests can distinguish between luminal A and B cancer subtypes; an extended follow-up examining occupational formaldehyde exposure...

miR-196a promotes the metastases of tumors

MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. High levels of miR-196a, a microRNA suppressing the expression of specific homebox genes that are of high relevance for the development of human embryo, activated oncogenic pathways inside human tumor cells and induced tumor cell dissemination....

Molecular structure could help explain albinism, melanoma

Scientists have long known that members of the phenoloxidase family are involved in skin and hair coloring. When they are mutated, they can cause albinism. Produced over abundantly, they are associated with melanoma. A team of Baylor College of Medicine and German researchers explain how hemocyanin is activated -- a finding that could lead to a better understanding of both ends of the skin and...

Monitoring water through a snake's eyes

Although most Americans take the safety of their drinking water for granted, that ordinary tap water could become deadly within minutes, says Prof. Abraham Katzir of Tel Aviv University's School of Physics and Astronomy.