Must mRNA be cloaked in a lipid coat to serve as a vaccine?

The Uchida Laboratory of Innovation Center of NanoMedicine has demonstrated that intradermal administration of mRNA alone (naked mRNA) without protection by nanoparticles induced robust vaccination against SARS CoV-2, a virus causing COVID-19, in mice and primates. mRNA is highly unstable, generally considered to require a tiny capsule, such as lipid nanoparticles (LNPs), for administration.