New test method to standardize immunological evaluation of nucleic acid nanoparticles

Therapeutic nucleic acids—lab-created segments of DNA or RNA, designed be used to block or modify genes, control gene expression or regulate other cellular processes—are a promising but still emerging area of biomedical treatment, with several drugs already in use and many more in trials. Nucleic acid nanoparticles (NANPs) are programmable assemblies made exclusively of nucleic acids with a number of therapeutic nucleic acid sequences embedded in their structure in a specific configuration, designed for the packaging and delivery of a number of intercellular or extracellular treatments simultaneously, to cause multiple, therapeutic actions human cells.