Scientists discover the mechanism of competition between mitochondrial genomes coexisting

Research at the Centro Nacional de Investigadores Cardiovasculares (CNIC) has identified the mechanism of competition between distinct mitochondrial genomes coexisting in the same cell. The study, published today in Science Advances, examines why the simultaneous presence of more than one variant of mitochondrial DNA (mtDNA) in a cell is rejected in most cells, which select a single mtDNA variant whose identity depends on the tissue.