It is thought that intestinal inflammatory conditions such as inflammatory bowel disease are exacerbated by depression. Now, new data have characterized a mechanism by which experimental conditions that induced depressive-like behaviors in mice increased susceptibility to intestinal inflammation. These data provide good rationale for future studies examining the clinical benefits of tricyclic antidepressants in individuals with inflammatory bowel disease.
Would tricyclic antidepressants help those with inflammatory bowel disease?
- EurekAlert
- 1. 5 2008 (06:00)