A new agent for the brain diseases: mRNA

Tokyo Medical and Dental University (TMDU) researchers prepared a nanomicelle delivery system to transport BDNF mRNA to the site of ischemic injury. The nanomicelle successfully produced BDNF and prevented the death of neurons when dosed 2 days after ischemia in rats. Long-term experiments showed significant improvements in memory compared with untreated rats. The findings are expected to extend the potential treatment window for preventing neuronal death after ischemic attack, and significantly improve outcomes for patients.