New York University biologists captured highly transient interactions between transcription factors—proteins that control gene expression—and target genes in the genome and showed that these typically missed interactions have important practical implications. In a new study published in Nature Communications, the researchers developed a method to capture transient interactions of NLP7, a master transcription factor involved in nitrogen use in plants, revealing that the majority of a plant's response to nitrogen is controlled by these short-lived regulatory interactions.
Biologists capture fleeting interactions between regulatory proteins and their genome-wide targets
- 2. 3 2020 (18:31)