This study reported for the first time, which identified the gene mutations and abnormal splicing of PLCg1 gene in AD using both high-throughput screening data and a deep learning-based prediction (Splice-AI)

Tokyo, Japan - Researchers from Tokyo Metropolitan University have revealed how liquid foams collapse by observing individual collapse "events" with high-speed video microscopy. They found that cracks in films led to a receding liquid front which sweeps up the original film border, inverts its shape, and releases a droplet which hits and breaks other films. Their observations and physical model...

Eminent scientists warn that key ecosystems around Australia and Antarctica are collapsing, and propose a three-step framework to combat irreversible global damage.

When it comes to learning to read, new research suggests that explicit instruction--a phonics teaching method in which the relationship between sound and spelling is taught directly and systematically--is more effective than self-discovery through reading.

The absence of the TRIM37 protein induces the formation of centrosomes in cells in turn favouring the development of tumours.

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise. Researchers at the DZNE come to this conclusion based on laboratory studies. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems.

Marilyn Rantz still remembers the day she got the call that her mother, whose health had been declining, had fallen and fractured her shoulder.

A number of brain areas change their activity before we execute a planned voluntary movement. A new study by Umeå University identifies a novel function of this preparatory neural activity, highlighting another mechanism the nervous system can use to achieve its goals.

Parasitic flatworms known as agents of food-borne zoonoses were confirmed to use several species of thiarid snails, commonly found in freshwater and brackish environments in southeast Asia, as their first intermediate host. These parasites can cause severe ocular infections in humans who consume raw or improperly cooked fish that have fed on parasitised snails. The study, conducted in South...

Based on a manual recently discovered in a 3,500-year-old medical papyrus, University of Copenhagen Egyptologist Sofie Schiødt has been able to reconstruct the embalming process used to prepare ancient Egyptians for the afterlife. It is the oldest surviving manual on mummification yet discovered.

Studies have shown that clonal hematopoiesis often goes hand in hand with atherosclerosis and cardiovascular disease. Since its discovery, this surprising association has been the subject of intense interest from clinicians and researchers alike. Patients with atherosclerosis suffer from hyperlipidemia and inflammation, two conditions that are known to chronically boost hematopoietic stem cell...

A Rice University computer science lab challenges -- and beats -- deep learning in a test to see if a new bioinformatics approach effectively tracks the lab of origin of a synthetic genetic sequence.

Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central nervous system. Potentially, it could be used to develop medications against Alzheimer's disease and other neurodegenerative conditions.

When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery.

Treatments for beating tumours are mainly based on CD8 T lymphocytes. This prompted a research team led by UNIGE to investigate CD4 T lymphocytes. The scientists found that when the CD4 T were directly put in close contact to the cancer cells, up to a third of them could also kill them. This discovery is significant and broadens the therapeutic perspectives based on administering CD4 T lymphocytes...

Rice University scientists have developed a greatly simplified method to make fluoroketones, a precursor for drug design and manufacture that typically requires an expensive silver catalyst.

Tohoku University researchers have produced cellulose nanofiber (CNF) synthesized silk naturally through a simple tweak to silkworms' diet. Mixing CNF with commercially available food and feeding the silkworms resulted in a stronger and more tensile silk.

In a new paper published in EPJ B Louis Bellando, a post-doctoral researcher at LOMA, University of Bordeaux, France, and his coauthors aim to numerically investigative the roles of cooperative effects and disorder in photon escape rates from a cold atomic gas to construct a model that considers the vectorial nature of light. Thus, the study accounts for properties of light, previously neglected.

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, including anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties. This study demonstrates that curcumin is a PPARα/γ dual activator and may affect expression levels of proteins involved in amyloid deposition and other...

New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement.

"Everyone's unique" is a popular maxim. All people are equal, but there are of course individual differences. This was no different with dinosaurs. A study by researchers at the University of Bonn and the Dinosaur Museum Frick in Switzerland has now revealed that the variability of Plateosaurus trossingensis was much greater than previously assumed. The paleontologists examined a total of 14...

Researchers at the Lady Davis Institute have identified a genetic remnant of our Neanderthal forebears that could be targeted to reduce the severity of COVID-19

Extremely low birth weight (ELBW) infants with moderate to large patent ductus arteriosus (PDA) may benefit from transcatheter PDA closure (TCPC) in the first four weeks of life, according to research published by Le Bonheur Cardiologist Ranjit Philip, MD, and Medical Director of Interventional Cardiac Imaging and Interventional Catheterization Laboratory Shyam Sathanandam, MD.

For practical applications, two-dimensional materials such as graphene must at some point connect with the ordinary world of 3D materials. MIT researchers have come up with a way of imaging what goes on at these interfaces, down to the level of individual atoms, with the goal of better controlling these materials' electronic properties.