337 articles from THURSDAY 3.9.2020

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A...

Democracys backsliding in the international environment

If the end of the 20th century was defined by the relatively widespread acceptance of democracy, the second decade of the 21st century is marked by concerns about backsliding in new and established democracies alike and by a notable decline in foreign support for democracy around the world. As democracy’s global tailwinds shift to headwinds, scholars have an opportunity to better understand...

Diversity and prosocial behavior

Immigration and globalization have spurred interest in the effects of ethnic diversity in Western societies. Most scholars focus on whether diversity undermines trust, social capital, and collective goods provision. However, the type of prosociality that helps heterogeneous societies function is different from the in-group solidarity that glues homogeneous communities together. Social cohesion in...

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine...

Evolution and epidemic spread of SARS-CoV-2 in Brazil

Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in...

False equivalencies: Online activism from left to right

Digital media are critical for contemporary activism—even low-effort "clicktivism" is politically consequential and contributes to offline participation. We argue that in the United States and throughout the industrialized West, left- and right-wing activists use digital and legacy media differently to achieve political goals. Although left-wing actors operate primarily through "hashtag...

Plants sustain the terrestrial silicon cycle during ecosystem retrogression

The biogeochemical silicon cycle influences global primary productivity and carbon cycling, yet changes in silicon sources and cycling during long-term development of terrestrial ecosystems remain poorly understood. Here, we show that terrestrial silicon cycling shifts from pedological to biological control during long-term ecosystem development along 2-million-year soil chronosequences in Western...