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257,373 articles from PhysOrg

New insights into an old drug: Scientists discover why aspirin works so well

New research has revealed important information about how aspirin works. Even though this drug has been available commercially since the late 1800s, scientists have not yet fully elucidated its detailed mechanism of action and cellular targets. The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.


Modeling agriculture matters for carbon cycling

To understand Earth's changing climate, scientists often turn to science-based computer simulations. Researchers strive to make these Earth system models as accurate as possible. Factors such as wind currents, air quality, and weather patterns all play a role. But current modeling has often overlooked one important activity: agriculture.

A wise tool for modifying microbes

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Some coastal salt marshes are keeping up with sea level rise—for now

The world's salty, tidal marshes are hotspots of carbon storage and productivity, building up sediments and plant material to stay above sea level. However, as sea level rises at an increasing rate, scientists debate whether it's possible for wetlands to win the race. New research reveals how salt marshes along the U.S. East Coast have responded to accelerating sea level rise by building elevation...

An epigenetic fingerprint as proof of origin for chicken, shrimp and salmon

Free-range organic chicken or factory farming? Scientists at the German Cancer Research Center (DKFZ) have developed a new detection method that can reveal such differences in husbandry. The so-called epigenetic method is based on the analysis of the characteristic patterns of chemical markers on the genome of the animals.

Highly charged ions melt nano gold nuggets

Normally, we have to make a choice in physics: Either we deal with big things—such as a metal plate and its material properties, or with tiny things—such as individual atoms. But there is also a world in between: The world of small but not yet tiny things, in which both effects of the macroscopic world and effects of the microscopic world play a role.

New method for fast, efficient and scalable cloud tomography

How do clouds shape the planet's future? Clouds are not just fluffy white shapes in the sky. They are vital for regulating the Earth's climate, as they influence the water cycle, atmospheric dynamics and energy balance. However, studying clouds is not easy. One way to do so is to use spaceborne imagers, but these imagers still face challenges of efficiency and scalability.

Fluorescent visualization and evaluation of NPC1L1-mediated cholesterol absorption at the levels of endocytic vesicles

Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease. The absorption of intestinal cholesterol is primarily mediated by Niemann-Pick C1-like 1 (NPC1L1) protein, which is responsible for about 70% cholesterol absorption. NPC1L1-deficient mice are resistant to...

New EU project will standardise access to biodiversity data to empower policymakers

The magnitude and dynamics of the global biodiversity crisis are hard to quantify and require rapid, reliable and repeatable biodiversity monitoring data which decision makers can use to evaluate policy options. Such information—from local to global level and within timescales relevant to policy—calls for improved integration of data on biodiversity from different sources such as museums,...