From a collection of molecules inspired by anti-parasitic medicines comes a potential drug candidate against COVID-19.

Last year, researchers reported that reductive stress -- an imbalance in the normal oxidation/reduction homeostasis -- caused pathological changes associated with heart failure in a mouse model. Now, researchers describe the putative molecular regulators of this pathological chronic reductive stress -- a microRNA network.

Pooled results from phase 3 clinical trials demonstrate that roxadustat is efficacious and may be comparable to placebo in studies done to date for treating anemia in patients with chronic kidney disease who do not require dialysis.

In a clinical trial of individuals at high risk for developing type 2 diabetes, which is the leading cause of kidney disease, vitamin D supplementation did not have significant effects on kidney health. As participants were not selected according to baseline vitamin D levels, investigators cannot exclude a kidney benefit for individuals with vitamin D deficiency.

Phytoplankton are the foundation of ocean ecosystems: like rainforests, they consume carbon from the atmosphere, form the basis of the marine food web and have a decisive influence on fish abundance and global climate. A recent study provides new insights into the complex biogeochemical processes at the base of the marine ecosystem.

Intense blooms of toxic algae are becoming common occurrences along the coast of Florida and elsewhere. Results from a new study found that wearing the face mask everyone has become accustomed to during the COVID-19 pandemic may help protect against these airborne toxins too.

A new device can detect SARS-CoV-2 from saliva in about an hour. Researchers report that the diagnostic is just as accurate as PCR tests and can identify COVID-19 variants.

Researchers have invented a cheaper, safer, and simpler technology that will allow a 'stubborn' group of metals, such as the Pt-group elements, to be transformed into thin films for various practical applications.

Researchers have revealed how the bacterium Streptococcus pneumoniae (pneumococcus) obtains the essential nutrient, manganese, from our bodies, which could lead to better therapies to target what is a life-threatening, antibiotic-resistant pathogen.

New research published in EPJ D combines mass spectroscopy with a range of other simulation and analytical techniques, allowing researchers to distinguish between two chiral forms of a dipeptide biomolecule.

In a new study published in EPJ D, researchers have clearly identified particular areas where discrepancies arise between theoretical and experimental measurements of helium ionization by an impacting proton.

A team of researchers has developed an immunotherapy strategy that can eliminate pancreatic tumors in mice. The new therapy, a combination of three drugs that boost the body's immune defenses against tumors, is expected to enter clinical trials later this year.

A licensed drug normally used to treat abnormal levels of fatty substances in the blood could reduce infection caused by the SARS-CoV-2 virus by up to 70 per cent, a new study in the laboratory reveals.

By manipulating the dopamine receptors of monkeys and studying their behavior, scientists reveal how our brain makes us feel motivated.

As people sheltered in place at the onset of the COVID-19 pandemic, sightings of wildlife in urban areas reinforced an intuitive belief: Carnivores were stretching their legs, and their ranges, by expanding into long-lost territory. But new research shows that mountain lions in Greater Los Angeles, when briefly spared the proximity of people, instead responded with an economy of movement that also...

Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma.

There is enough water on our planet, but by far the largest part is salt water that is unsuitable as drinking water. Therefore, especially in dry regions of the earth, the search for new freshwater resources is very active. An international team of researchers has now discovered strong evidence of a groundwater deposit off the coast of Malta.

Researchers call for a shift in focus away from risks of 'super-volcanic' eruptions and towards likelier scenarios of smaller eruptions in key global 'pinch points' creating devastating domino effects.

It was long assumed that cyanobacteria were mainly responsible for fixing nitrogen on early Earth, thus making nitrogen available to the biosphere. Researchers now show that purple sulfur bacteria could have contributed substantially to nitrogen fixation under the conditions prevailing in the Proterozoic ocean.

The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, seven months after infection, according to a follow-up study in a cohort of healthcare workers. The results also support the idea that pre-existing antibodies against common cold coronaviruses could protect against COVID-19.

Chronic stress is a well-known cause for mental health disorders. New research has moved a step forward in understanding how glucocorticoid hormones ('stress hormones') act upon the brain and what their function is. The findings could lead to more effective strategies in the prevention and treatment of mental health disorders.

Three dimensional (3D) nano-network promise a new era in modern solid state physics with numerous applications in photonics, bio-medicine, and spintronics. The realization of 3D magnetic nano-architectures could enable ultra-fast and low-energy data storage devices. Due to competing magnetic interactions in these systems magnetic charges or magnetic monopoles can emerge, which can be utilized as...

A new special edition of EPJ Special Topics brings together several papers that detail our understanding of Quark-Gluon Plasma (QGP) and the processes that transformed it into the baryonic matter we around us on an everyday basis.

The research found that photobiomodulation -- a form of low-dose light therapy -- sped up recovery from burns and reduced inflammation in mice by activating a protein that controls cell growth and division.