Researchers uncovered the role of the third intracellular loop in the G protein-coupled receptors' signaling mechanism, which could lead to a more targeted approach to drug discovery and a paradigm shift for new therapeutics.

Researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.

Researchers outline the complexities of young-onset colorectal cancer and the research needed to map out a path toward understanding it.

A new process that lets scientists chemically cut apart and stitch together nanoscopic layers of two-dimensional materials -- like a tailor altering a suit -- could be just the tool for designing the technology of a sustainable energy future. Researchers have developed a method for structurally splitting, editing and reconstituting layered materials, called MAX phases and MXenes, with the...

An artificial pancreas improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study.

More donated hearts could be suitable for transplantation if they are kept functioning within the body for a short time following the death of the donor, new research has concluded.

Most cities don't map their own pedestrian networks. Now, researchers have built the first open-source tool to let planners do just that. Researchers have built TILE2NET, an open-source tool that uses aerial imagery and image-recognition to create complete maps of sidewalks and crosswalks. The tool can help planners, policymakers, and urbanists who want to expand pedestrian infrastructure.

A new approach that delivers a 'one-two punch' to help T cells attack solid tumors is the focus of a preclinical study. The findings showed that targeting two regulators that control gene functions related to inflammation led to at least 10 times greater T cell expansion in models, resulting in increased anti-tumor immune activity and durability.

An increasing number of U.S. interstates are set to try out an invention that could save millions of taxpayer dollars and significantly reduce traffic delays. The invention, a sensor that allows concrete to 'talk,' decreases construction time and how often concrete pavement needs repairs while also improving the road’s sustainability and cutting its carbon footprint. Embedded directly into a...

A new study is providing an unprecedented examination of oxygen loss on coral reefs around the globe under ocean warming. The study captures the current state of hypoxia -- or low oxygen levels -- at 32 different sites, and reveals that hypoxia is already pervasive on many reefs.

In a Phase II trial, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC). New findings from the NEOSTAR trial, published today in Nature Medicine, provide further support for neoadjuvant...

Intense fishing and over-exploitation have led to evolutionary changes in fish stocks like cod, reducing both their productivity and value on the market. These changes can be reversed by more sustainable and far-sighted fisheries management. A new study shows that reversal of evolutionary change would only slightly reduce the profit of fishing, but would help regain and conserve natural genetic...

New research has shown that a strong coupling of light and material increases the colour brilliance of OLED displays. This increase is independent of the viewing angle and does not affect energy efficiency.

Compass readings that do not show the direction of true north and interference with the operations of satellites are a few of the problems caused by peculiarities of the Earth's magnetic field. The magnetic field radiates around the world and far into space, but it is set by processes that happen deep within the Earth's core, where temperatures exceed 5,000-degrees C. New research from...

Criteria used by neurologists to assess for multiple sclerosis (MS) in adults may fail to identify the illness in children with imaging suspicious for the disease, an oversight that could delay treatment of the disease at its earliest stages, according to a new study.

Researchers have shown how energy disappears in quantum turbulence, paving the way for a better understanding of turbulence in scales ranging from the microscopic to the planetary. The team's findings demonstrate a new understanding of how wave-like motion transfers energy from macroscopic to microscopic length scales, and their results confirm a theoretical prediction about how the energy is...

In a new study, astronomers describe how extraterrestrial life has the potential to exist on distant exoplanets inside a special area called the 'terminator zone,' which is a ring on planets that have one side that always faces its star and one side that is always dark.

Solar cells made from metal halide perovskites achieve high efficiencies and their production from liquid inks requires only a small amount of energy. Scientists are investigating the production process. At the X-ray source BESSY II, the group has analyzed the optimal composition of precursor inks for the production of high-quality FAPbI3 perovskite thin films by slot-die coating. The solar cells...

Flatburn is an open-source, mobile pollution detector intended to let people measure air quality cheaply.

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

Researchers have reported a novel method of harvesting water from naturally occurring sources such as fog and dew.

Preterm infants do not get used to repeated pain in the way that full-term infants, children and adults do habituate to pain, finds a new study.

A small nucleus in the brainstem called locus coeruleus (literally the 'blue spot,') is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the 'fight or flight' response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons. A recent pioneering study now reveals the cellular...

Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours.