CAR T cell therapy has revolutionized the way certain types of cancer are treated, and the longer those CAR T cells live in a patient's body, the more effectively they respond to cancer. Now, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in...

Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.

A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.

The potential of quantum technology is huge but is today largely limited to the extremely cold environments of laboratories. Now, researchers have succeeded in demonstrating for the very first time how laser light can induce quantum behavior at room temperature -- and make non-magnetic materials magnetic. The breakthrough is expected to pave the way for faster and more energy-efficient computers,...

Forests could also be potential bulwarks against climate change. But, increasingly severe droughts and wildfires, invasive species, and large insect outbreaks -- all intensified by climate change -- are straining many national forests and surrounding lands in the United States. A report outlines a new approach to forest stewardship that 'braids together' Indigenous knowledge and Western science to...

Undertaking the majority of daily physical activity in the evening is linked to the greatest health benefits for people living with obesity, according to researchers who followed the trajectory of 30,000 people over almost 8 years.

Over 12 million people worldwide suffer from a chronic infection with the hepatitis D virus. This most severe viral liver disease is associated with a high risk of dying from liver cirrhosis and liver cancer. It is caused by the hepatitis D virus (HDV), which uses the surface proteins of the hepatitis B virus (HBV) as a vehicle to specifically enter liver cells via a protein in the cell membrane...

New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the activity of coregulator proteins.

Early jawless fish were likely to have used bony projections surrounding their mouths to modify the mouth's shape while they collected food. Experts have used CT scanning techniques to build up the first 3D pictures of these creatures, which are some of the earliest vertebrates (animals with backbones) in which the mouth is fossilized. Their aim was to answer questions about feeding in early...

Only recently, a new era in medicine began with the first RNA vaccines. These active substances are modified RNAs that trigger immune responses of the human immune system. Another approach in RNA medicine targets the body's own RNA and its protein modulators by specifically tailored active substances.

A research team has developed a broadband UV dual-comb spectrometer with which air pollutants can be continually measured and their reaction with the environment can be observed in real time.

Children and young people who are overweight or obese are at significantly higher risk of iron deficiency, according to a study by nutritional scientists.

Researchers applied artificial intelligence (AI) to a technique that produces high-resolution images of cells in the eye. They report that with AI, imaging is 100 times faster and improves image contrast 3.5-fold. The advance, they say, will provide researchers with a better tool to evaluate age-related macular degeneration (AMD) and other retinal diseases.

Researchers have discovered the connection between aldehydes, organic compounds produced by cells as part of metabolic processes, and rapid aging. Their findings indicate a potential treatment for diseases that lead to accelerated aging as well as a means to counteract aging in healthy people by controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.

The path to quantum supremacy is made challenging by the issues associated with scaling up the number of qubits. One key problem is the way that qubits are measured. A research group introduces a new approach that tackles these challenges head-on using nanobolometers instead of traditional, bulky parametric amplifiers.

Research has uncovered important new insights into the evolution of oxygen, carbon, and other vital elements over the entire history of Earth -- and it could help assess which other planets can develop life, ranging from plants to animals and humans.

Researchers have developed a digital display screen where the LEDs themselves react to touch, light, fingerprints and the user's pulse, among other things. Their results could be the start of a whole new generation of displays for phones, computers and tablets.

Scientists have identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV.

Chemists show that a machine-based method prevents widespread 'bias' in chemical publications.

Researchers decode repair mechanism during transcription of genetic information.

When scuba divers need to say 'I'm okay' or 'Shark!' to their dive partners, they use hand signals to communicate visually. But sometimes these movements are difficult to see. Now, researchers have constructed a waterproof 'e-glove' that wirelessly transmits hand gestures made underwater to a computer that translates them into messages. The new technology could someday help divers communicate...

Forensic and environmental experts have teamed up to develop a new scientific method to pinpoint microplastic pollution 'hotspots' in open waters.

Over 200 million people around the world experience peripheral artery disease (PAD) -- a condition caused by the narrowing of the blood vessels from the heart to the lower limbs that leads to pain when walking -- and for roughly 1-in-10 this advances to chronic limb-threatening ischemia (CLTI), an advanced form of PAD. Those with CLTI often suffer severe pain even at rest, caused by fatty plaque...

A large randomized trial shows that a new three-step prostate cancer screening method can find a considerable number of aggressive cancers. Population-level screening programs have not been launched in most countries.